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> Pathway Inhibitors>Protein Inhibitors>TA-8995 (Obicetrapib )

Protein Inhibitors

Ta-8995 View larger

TA-8995 (Obicetrapib )

AOB31310

CAS 866399-87-3

Chemical Name: Obicetrapib; AMG-899; 4-[2-[[3,5-Bis(trifluoromethyl)phenyl]methyl-[(2R,4S)-1-ethoxycarbonyl-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinolin-4-yl]amino]pyrimidin-5-yl]oxybutanoic acid

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $31.45 Total: $157.25
110 $26.64 Total: $266.40
125 $22.57 Total: $564.25
150 $19.24 Total: $962.00
1100 $16.65 Total: $1,665.00

Data sheet

Molecular FormulaC32H31F9N4O5
Molecular Weight722.61
CAS Numbers866399-87-3 (free acid)
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymObicetrapib; AMG-899; AMG 899; AMG899; TA-8995; TA8995; TA 8995; DEZ-001; DEZ 001; DEZ001.
IUPAC/Chemical Name4-((2-((3,5-bis(trifluoromethyl)benzyl)((2R,4S)-1-(ethoxycarbonyl)-2-ethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinolin-4-yl)amino)pyrimidin-5-yl)oxy)butanoic acid
InChl KeyNRWORBQAOQVYBJ-GJZUVCINSA-N
InChl Code InChI=1S/C32H31F9N4O5/c1-3-22-14-26(24-13-19(30(33,34)35)7-8-25(24)45(22)29(48)49-4-2)44(28-42-15-23(16-43-28)50-9-5-6-27(46)47)17-18-10-20(31(36,37)38)12-21(11-18)32(39,40)41/h7-8,10-13,15-16,22,26H,3-6,9,14,17H2,1-2H3,(H,46,47)/t22-,26+/m1/s1
SMILES CodeO=C(O)CCCOC1=CN=C(N(CC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)[C@H]3C[C@@H](CC)N(C(OCC)=O)C4=C3C=C(C(F)(F)F)C=C4)N=C1
References1) Martin SS., et al., Comparison of low-density lipoprotein cholesterol equations in patients with dyslipidaemia receiving cholesterol ester transfer protein inhibition. Eur Heart J Cardiovasc Pharmacother. 2023 Feb 2;9(2):148-155. doi: 10.1093/ehjcvp/pvac056. PMID: 36307922; PMCID: PMC9892865.

2) Taheri H,et al., Cholesteryl Ester Transfer Protein Inhibitors and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Cardiology. 2020;145(4):236-250. doi: 10.1159/000505365. Epub 2020 Mar 13. PMID: 32172237.

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Novel potent and selective cholesterol esterase transfer protein (CETP) inhibitor