Protein Inhibitors

AC220 View larger

AC220

AOB87793

CAS No:950769-58-1

Chemical Names: Quizartinib, AC010220

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$21.00

$21.00 per mg

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Quantity Discount Table - Order More To Get More Price Discount

Quantity (mg or Unit)Unit Price ($/mg or $/Unit)Final Price
100 $9.45 Total: $945.00
50 $10.92 Total: $546.00
25 $12.81 Total: $320.25
10 $15.12 Total: $151.20
5 $17.85 Total: $89.25

Data sheet

Molecular FormulaC29H32N6O4S
Molecular Weight506.67
CAS Numbers950769-58-1
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity99% (HPLC)
IUPAC/Chemical Name1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-(7-(2-morpholinoethoxy)benzo[d]imidazo[2,1-b]thiazol-2-yl)phenyl)urea
InChl KeyInChi Key: CVWXJKQAOSCOAB-UHFFFAOYSA-N
SMILES CodeO=C(NC1=CC=C(C2=CN3C(SC4=CC(OCCN5CCOCC5)=CC=C34)=N2)C=C1)NC6=NOC(C(C)(C)C)=C6
References1) Smith CC, etc. Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397. Cancer Discov. 2015 Jun;5(6):668-79.

2) Zorn JA, Wang Q, Fujimura E, Barros T, Kuriyan J. Crystal structure of the FLT3 kinase domain bound to the inhibitor Quizartinib (AC220). PLoS One. 2015 Apr 2;10(4):e0121177.

More info

A selective and orally bioavailable inhibitor of FLT3