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TH7299
AOB10412
CAS: 1415648-20-2
Chemical Name: (4-(3-(4,6-Diamino-2-oxo-1,2-dihydropyridin-3-yl)ureido)benzoyl)-L-glutamic acid
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $31.05 | Total: $3,105.00 |
| 1 | 50 | $35.88 | Total: $1,794.00 |
| 1 | 25 | $42.09 | Total: $1,052.25 |
| 1 | 10 | $49.68 | Total: $496.80 |
| 1 | 5 | $58.65 | Total: $293.25 |
Data sheet
| Molecular Formula | C18H20N6O7 |
| Molecular Weight | 432.39 |
| CAS Numbers | 1415648-20-2 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | TH 7299, TH-7299 |
| IUPAC/Chemical Name | (4-(3-(4,6-Diamino-2-oxo-1,2-dihydropyridin-3-yl)ureido)benzoyl)-L-glutamic acid |
| InChl Key | XYBHHWPTCKDMPA-NSHDSACASA-N |
| InChl Code | InChI=1S/C18H20N6O7/c19-10-7-12(20)23-16(28)14(10)24-18(31)21-9-3-1-8(2-4-9)15(27)22-11(17(29)30)5-6-13(25)26/h1-4,7,11H,5-6H2,(H,22,27)(H,25,26)(H,29,30)(H2,21,24,31)(H5,19,20,23,28)/t11-/m0/s1 |
| SMILES Code | O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NC(NC2=C(N)C=C(N)NC2=O)=O)C=C1)=O |
| References | 1) Green AC, et al. Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells. Nat Metab. 2023 Apr;5(4):642-659. doi: 10.1038/s42255-023-00771-5. Epub 2023 Apr 3. PMID: 37012496; PMCID: PMC10132981.2) Bonagas, N., et al. Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nat Cancer 3, 156–172 (2022). https://doi.org/10.1038/s43018-022-00331-y |
More info
First-in-class MTHFD2 inhibitor, impairing cancer progression in vivo, preventing thymidine production leading to misincorporation of uracil into DNA and replication stress