Protein Inhibitors

Ruxolitinib phosphate View larger

Ruxolitinib phosphate

AT3043

CAS 1092939-17-7

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$37.00

$37.00 per 5 mg

Data sheet

Molecular FormulaC17H21N6O4P
Molecular Weight404.36
CAS Numbers1092939-17-7
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeOP(O)(O)=O.N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
ReferencesQuintas-Cardama A, et al. Preclinical characterization of the selective JAK12 inhibitor INCB018424 therapeutic implications for the treatment of myeloproliferative neoplasms. Blood, 2010, 115[15], 3109-3117.

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Ruxolitinib phosphate (INCB018424)(INCB018424 phosphate) is the first potent, selective, JAK12 inhibitor to enter the clinic with IC50 of 3.3 nM2.8 nM, >130-fold selectivity for JAK12 versus JAK3.