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View larger Ruxolitinib phosphate
AT3043
CAS 1092939-17-7
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Data sheet
| Molecular Formula | C17H21N6O4P |
| Molecular Weight | 404.36 |
| CAS Numbers | 1092939-17-7 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | OP(O)(O)=O.N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12 |
| References | Quintas-Cardama A, et al. Preclinical characterization of the selective JAK12 inhibitor INCB018424 therapeutic implications for the treatment of myeloproliferative neoplasms. Blood, 2010, 115[15], 3109-3117. |
More info
Ruxolitinib phosphate (INCB018424)(INCB018424 phosphate) is the first potent, selective, JAK12 inhibitor to enter the clinic with IC50 of 3.3 nM2.8 nM, >130-fold selectivity for JAK12 versus JAK3.