Protein Inhibitors

MPP+ iodide View larger

MPP+ iodide

AT9169

CAS 36913-39-0

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$28.00

$28.00 per 5 mg

Data sheet

Molecular FormulaC12H12IN
Molecular Weight297.13
CAS Numbers36913-39-0
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeI.c1ccc(cc1)-c1ccncc1
ReferencesZhao M, et al. Mitochondrial calcium dysfunction contributes to autophagic cell death induced by MPP+ via AMPK pathway. Biochem Biophys Res Commun. 2019 Feb 5;509[2] 390-394.

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MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells.