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View larger AZ10606120 dihydrochloride
AT14366
CAS 607378-18-7
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $44.20 | Total: $221.00 |
| 1 | 10 | $37.44 | Total: $374.40 |
| 1 | 25 | $31.72 | Total: $793.00 |
| 1 | 50 | $27.04 | Total: $1,352.00 |
| 1 | 100 | $23.40 | Total: $2,340.00 |
Data sheet
| Molecular Formula | C25H36Cl2N4O2 |
| Molecular Weight | 495.48 |
| CAS Numbers | 607378-18-7 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cl.Cl.OCCNCCNc1ccc2c(NC(=O)CC34CC5CC(CC(C5)C3)C4)cccc2n1 |
| References | Allsopp RC, et al. Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120. Sci Rep. 2017 Apr 7;7[1] 725. |
More info
AZ10606120 dihydrochloride is a selectable, potent, high-affinity receptor antagonist with K D values of 1.4 and 19 nM at human and rat P2X 7 receptors, respectively. AZ10606120 dihydrochloride inhibits tumor growth and has anti-angiogenic activity. AZ 10606120 acts as a negative allosteric modulator when bound to a site coupled to the ATP binding site.