Purinergic Receptors

BAY 60-6583 View larger

BAY 60-6583

AT14506

CAS 910487-58-0

More details

Molarity Calculation Cart®

HOW TO ORDER

$35.00

$35.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $15.75 Total: $1,575.00
150 $18.20 Total: $910.00
125 $21.35 Total: $533.75
110 $25.20 Total: $252.00
15 $29.75 Total: $148.75

Data sheet

Molecular FormulaC19H17N5O2S
Molecular Weight379.44
CAS Numbers910487-58-0
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeNC(=O)CSc1nc(N)c(C#N)c(-c2ccc(OCC3CC3)cc2)c1C#N
ReferencesAherne CM, et al. Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis.Mucosal Immunol. 2015 Nov;8[6] 1324-38.

More info

BAY 60-6583 is a potent, high-affinity adenosine A2B receptor agonist (EC50 = 3 nM) with affinity for A2B receptors that exceeds that for A1, A2A, and A3 receptors.BAY 60-6583 is cardioprotective in a model of myocardial ischemia.The Ki values for BAY 60-6583 binding to mouse, rabbit, and dog A2BAR were 750 nM, 340 nM, and 330 nM, respectively. The Ki values of BAY 60-6583 binding to A2BAR in mice, rabbits and dogs were 750 nM, 340 nM and 330 nM respectively.