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Purinergic Receptors
- Protein Control Ligand
- Pathway Inhibitors
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- Kinase Inhibitors
- Protease
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- p18
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- Hydroxylases
- Ubiquitin-Activating Enzyme
- Adenosine Deaminase
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- Neprilysin
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- Topoisomerase
- Transferase
- Protein Inhibitors
- Transporter Inhibitors
- Cell Inhibition
- Synthase
- Receptor Tyrosine Phosphatases (RTP)
- AChE
- Peptidase
- Autophagy
- Toll-Like Receptor (TLR)
- Enzyme Inhibitors
- Function Modulators
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- G Protein-Coupled Receptor Ligands
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- Adrenoceptor
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- Cannabinoid Receptors
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- Ghrelin Receptors
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- Ryanodine receptor
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- Urotensin Receptor
- Imidazoline receptor
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- β-arrestin/β2-adaptin
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- Biomarkers and Buffer Solutions
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- Molecular Glues
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- SARS-CoV
View larger Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $22.10 | Total: $110.50 |
| 1 | 10 | $18.72 | Total: $187.20 |
| 1 | 25 | $15.86 | Total: $396.50 |
| 1 | 50 | $13.52 | Total: $676.00 |
| 1 | 100 | $11.70 | Total: $1,170.00 |
Data sheet
| Molecular Formula | C23H26N4O5S |
| Molecular Weight | 470.54 |
| CAS Numbers | 919351-41-0 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CCOC(=O)c1cc(C#N)c(nc1C)N1CCC(CC1)C(=O)NS(=O)(=O)Cc1ccccc1 |
| References | Bach P,et al. Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283. J Med Chem. 2013 Sep 12;56[17] 7015-24. |
More info
AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ugkgmin, binding IC50: 11 nM). AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregation with antithrombotic ED50 values of 3.0 and 10 ?gkgmin, respectively. The doses induced the increase in bleeding time at 33 and 100 ?gkgmin for 3- and 13-fold, respectively. Thus, the therapeutic index (TI) was ?10 for both compounds.