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View larger Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $22.95 | Total: $2,295.00 |
| 1 | 50 | $26.52 | Total: $1,326.00 |
| 1 | 25 | $31.11 | Total: $777.75 |
| 1 | 10 | $36.72 | Total: $367.20 |
| 1 | 5 | $43.35 | Total: $216.75 |
Data sheet
| Molecular Formula | C17H10F6N6O |
| Molecular Weight | 428.29 |
| CAS Numbers | 1642300-52-4 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | NC(=O)C(=Cn1cnc(n1)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1cncnc1 |
| References | Vercruysse T et al. The second-generation exportin-1 inhibitor KPT-8602 demonstrates potent activity against acute lymphoblastic leukemia. Clin Cancer Res. 2016 Oct 25. |
More info
Eltanexor (ONO-7706) is an orally active exportin-1 (XPO1) inhibitor. It has effective anti-leukemic activity. Eltanexor inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor causes caspase-dependent apoptosis in a panel of leukemic cell lines.