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GNF362

AT11446

CAS 1003019-41-7

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$339.00

$339.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $152.55 Total: $15,255.00
150 $176.28 Total: $8,814.00
125 $206.79 Total: $5,169.75
110 $244.08 Total: $2,440.80
15 $288.15 Total: $1,440.75

Data sheet

Molecular FormulaC22H21F3N6
Molecular Weight426.44
CAS Numbers1003019-41-7
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeC[C@@H]1CN(Cc2cn[nH]c2-c2ccc(cc2)C#N)CCN1c1ccc(cn1)C(F)(F)F
ReferencesMiller AT, et al. Conversion of antigen-specific effectormemory T cells into Foxp3-expressing Treg cells by inhibition of CDK819. Sci Immunol. 2019 Oct 25;4[40]. pii eaaw2707.

More info

GNF362 is an orally available, selective and potent inhibitor of inositol trisphosphate 3'kinase B (ITPKB), inhibits Itpka and Itpkc, overcomes TMZ chemoresistance, and selectively deletes donor allogeneic reactive T-cells.GNF362 reverses the migratory stimulatory effects of ITPKA overexpression.