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> Rare Chemicals>Tat-NR2B9c acetate

Rare Chemicals

Tat-NR2B9c acetate View larger

Tat-NR2B9c acetate

AT13112L1

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$69.00

$69.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $58.65 Total: $293.25
110 $49.68 Total: $496.80
125 $42.09 Total: $1,052.25
150 $35.88 Total: $1,794.00
1100 $31.05 Total: $3,105.00

Data sheet

Molecular FormulaC107H192N42O32
Molecular Weight2578.93
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCC(C)[C@@H](C(O)=O)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CO)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC(CNC([C@H](CC1=CC=C(O)C=C1)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.CC(O)=O
ReferencesCui H, et al. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci. 2007 Sep 12;27[37] 9901-15.

More info

Tat-NR2B9c acetate (NA-1 acetate) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c acetate disrupts the PSD-95NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 ?M and 8 ?M, respectively. Tat-NR2B9c acetate also inhibits neuronal nitric oxide synthase (nNOS)PSD-95 interaction, and possesses neuroprotective efficacy.