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View larger Simufilam dihydrochloride
AT9172
CAS 2480226-06-8
Molarity Calculation Cart®
HOW TO ORDER
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $28.35 | Total: $2,835.00 |
| 1 | 50 | $32.76 | Total: $1,638.00 |
| 1 | 25 | $38.43 | Total: $960.75 |
| 1 | 10 | $45.36 | Total: $453.60 |
| 1 | 5 | $53.55 | Total: $267.75 |
Data sheet
| Molecular Formula | C15H23Cl2N3O |
| Molecular Weight | 332.3 |
| CAS Numbers | 2480226-06-8 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | [H]Cl.O=C1N(CC2=CC=CC=C2)C3(CCN(C)CC3)NC1.[H]Cl |
| References | Wang HY, et al. PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis. Neurobiol Aging. 2017;55 99-114. |
More info
Simufilam dihydrochloride (PTI-125 dihydrochloride) is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its ?7nAChRTLR4 associations and downstream pathologies.