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View larger PF-06446846 hydrochloride
AT16491
CAS 1632250-50-0
Molarity Calculation Cart®
HOW TO ORDER
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $34.65 | Total: $3,465.00 |
| 1 | 50 | $40.04 | Total: $2,002.00 |
| 1 | 25 | $46.97 | Total: $1,174.25 |
| 1 | 10 | $55.44 | Total: $554.40 |
| 1 | 5 | $65.45 | Total: $327.25 |
Data sheet
| Molecular Formula | C22H20CIN7O.XHCl |
| CAS Numbers | 1632250-50-0 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cl.Clc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-n1nnc2cccnc12 |
| References | Lintner NG, et al. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. PLoS Biol. 2017 Mar 21;15[3] e2001882. |
More info
PF-06446846 hydrochloride, an orally active and highly selective inhibitor, targets Proprotein Convertase SubtilisinKexin type 9 (PCSK9) translation by inducing ribosomal stalling at approximately codon 34, effectively suppressing PCSK9 expression.