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> Rare Chemicals>Cyclosporin H

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Cyclosporin H View larger

Cyclosporin H

AT21493

CAS 83602-39-5

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$106.00

$106.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $90.10 Total: $450.50
110 $76.32 Total: $763.20
125 $64.66 Total: $1,616.50
150 $55.12 Total: $2,756.00
1100 $47.70 Total: $4,770.00

Data sheet

Molecular FormulaC62H111N11O12
Molecular Weight1202.61
CAS Numbers83602-39-5
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCC=CC[C@H](C)[C@H](O)C1N(C)C(=O)[C@@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)CCCNC1=O)C(C)C
ReferencesZhang X, et al. Mitochondrial peptides cause proinflammatory responses in the alveolar epithelium via FPR-1, MAPKs, and AKT a potential mechanism involved in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2018;315[5] L775-L786.

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Cyclosporin H (CsH), a specific inhibitor of FPR1, inhibited lung inflammation in the ALI models. CsH significantly attenuated MTDs or NFP-induced inflammatory lung injury and activation of MAPK and AKT pathways. Cyclosporin H is a viral transduction enhancer which increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). When combined with Rapamycin or Prostaglandin E2 Cyclosporin H displays an additive effect. Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.