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> Rare Chemicals>Rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b]pyrazine

Rare Chemicals

Rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b]pyrazine View larger

Rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b]pyrazine

AT62750L

CAS 2738485-99-7

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QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $231.20 Total: $1,156.00
110 $195.84 Total: $1,958.40
125 $165.92 Total: $4,148.00
150 $141.44 Total: $7,072.00
1100 $122.40 Total: $12,240.00

Data sheet

Molecular FormulaC24H23ClFN5O
Molecular Weight451.92
CAS Numbers2738485-99-7
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCC1=NC=2C(=NC(=CC2N=C1C)[C@@H]3C[C@@H](OCC3)C4=CN(C)N=C4)C5=C(F)C=C(Cl)C=C5
ReferencesWhite RD, et al. Preparation of heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use. WO2021226629 A1.

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rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b]pyrazine has an EC50 value of ? 0.05 ?M and an E.max value of > 250 ?M for TREM2.