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> Pathway Inhibitors>Enzyme Inhibitors>RAS>J-104871

RAS

J-104871 View larger

J-104871

AT24188

CAS 191088-19-4

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$166.00

$166.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $141.10 Total: $705.50
110 $119.52 Total: $1,195.20
125 $101.26 Total: $2,531.50
150 $86.32 Total: $4,316.00
1100 $74.70 Total: $7,470.00

Data sheet

Molecular FormulaC38H32N2O12
Molecular Weight708.67
CAS Numbers191088-19-4
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeC(O)(=O)C1(C(O)=O)O[C@H](C(N([C@@H]([C@H](CC=CC2=NC=3C(O2)=CC=CC3)C=4C=C5C(=CC4)OCO5)C)CC6=CC7=C(C=C6)C=CC=C7)=O)[C@H](C(O)=O)O1
ReferencesYonemoto M, Satoh T, Arakawa H, Suzuki-Takahashi I, Monden Y, Kodera T, Tanaka K, Aoyama T, Iwasawa Y, Kamei T, Nishimura S, Tomimoto K. J-104,871, a novel farnesyltransferase inhibitor, blocks Ras farnesylation in vivo in a farnesyl pyrophosphate-competitive manner. Mol Pharmacol. 1998 Jul;54[1] 1-7. PubMed PMID 9658183.

More info

J-104871 (UNII-6137X5QNJF) is a novel farnesyltransferase (FTase) inhibitor that competitively blocks Ras farnesylation in vivo, inhibits Ras processing in activated H-ras-transformed NIH3T3 cells, and suppresses tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.