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GPR120-IN-1
AOB14111
CAS: 337495-81-5
Chemical Name: 3-(4-Methylphenyl)-2-[(2-oxo-2-phenylethyl)sulfanyl]-5,6-dihydrospiro(benzo[h]quinazoline-5,1'-cyclopentane)-4(3H)-one
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $58.05 | Total: $5,805.00 |
| 1 | 50 | $67.08 | Total: $3,354.00 |
| 1 | 25 | $78.69 | Total: $1,967.25 |
| 1 | 10 | $92.88 | Total: $928.80 |
| 1 | 5 | $109.65 | Total: $548.25 |
Data sheet
| Molecular Formula | C31H28N2O2S |
| Molecular Weight | 492.64 |
| CAS Numbers | 337495-81-5 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | GPR120-IN-1; GPR120IN-1; GPR120 IN-1; GPR120-IN1; GPR120-IN 1; GPR120IN1; GPR120 IN 1; |
| IUPAC/Chemical Name | 2-((2-oxo-2-phenylethyl)thio)-3-(p-tolyl)-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-4(6H)-one |
| InChl Key | QZWDOYVXGVZXFI-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C31H28N2O2S/c1-21-13-15-24(16-14-21)33-29(35)27-28(32-30(33)36-20-26(34)22-9-3-2-4-10-22)25-12-6-5-11-23(25)19-31(27)17-7-8-18-31/h2-6,9-16H,7-8,17-20H2,1H3 |
| SMILES Code | O=C1N(C2=CC=C(C)C=C2)C(SCC(C3=CC=CC=C3)=O)=NC4=C1C5(CCCC5)CC6=CC=CC=C64 |
| References | 1) AjayPal et al., In silico and in vitro screening for potential anticancer candidates targeting GPR120, Bioorganic & Medicinal Chemistry Letters Volume 31, 1 January 2021, 127672 |
More info
Novel GPR120 inhibitor, showing ~90% inhibitory effects on cell growth with micromolar affinities (IC50 = 23.21- 26.69µM) against SW480