Steroid Hormone Receptors

KYN-101 View larger

KYN-101

AOB11039

CAS: 2247950-73-6

 

Chemical Name: N-(2-(1H-Indol-3-yl)ethyl)-5-(5-fluoropyridin-3-yl)-3-methylpyrazolo[1,5-a]pyrimidin-7-amine

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$29.00

$29.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $13.05 Total: $1,305.00
150 $15.08 Total: $754.00
125 $17.69 Total: $442.25
110 $20.88 Total: $208.80
15 $24.65 Total: $123.25

Data sheet

Molecular FormulaC22H19FN6
Molecular Weight386.43
CAS Numbers2247950-73-6
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymKYN-101; KYN 101; KYN101
IUPAC/Chemical NameN-(2-(1H-Indol-3-yl)ethyl)-5-(5-fluoropyridin-3-yl)-3-methylpyrazolo[1,5-a]pyrimidin-7-amine
InChl KeyDCXVYXPVNSMWPG-IAGOWNOFSA-N
InChl CodeInChI=1S/C22H19FN6/c1-14-10-27-29-21(9-20(28-22(14)29)16-8-17(23)13-24-11-16)25-7-6-15-12-26-19-5-3-2-4-18(15)19/h2-5,8-13,25-26H,6-7H2,1H3
SMILES CodeCC1=C2N=C(C3=CC(F)=CN=C3)C=C(NCCC4=CNC5=C4C=CC=C5)N2N=C1
References1) Luis Felipe Campesato et al., Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine, Nature Communications volume 11, Article number: 4011 (2020)

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Novel potent and selective inhibitor of aryl hydrocarbon receptor (AHR) (IC50 of 22 nM in the human HepG2 DRE-luciferase reporter assay and 23 nM in the murine Hepa1 Cyp-luc assay)

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