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View larger KYN-101
AOB11039
CAS: 2247950-73-6
Chemical Name: N-(2-(1H-Indol-3-yl)ethyl)-5-(5-fluoropyridin-3-yl)-3-methylpyrazolo[1,5-a]pyrimidin-7-amine
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $24.65 | Total: $123.25 |
| 1 | 10 | $20.88 | Total: $208.80 |
| 1 | 25 | $17.69 | Total: $442.25 |
| 1 | 50 | $15.08 | Total: $754.00 |
| 1 | 100 | $13.05 | Total: $1,305.00 |
Data sheet
| Molecular Formula | C22H19FN6 |
| Molecular Weight | 386.43 |
| CAS Numbers | 2247950-73-6 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | KYN-101; KYN 101; KYN101 |
| IUPAC/Chemical Name | N-(2-(1H-Indol-3-yl)ethyl)-5-(5-fluoropyridin-3-yl)-3-methylpyrazolo[1,5-a]pyrimidin-7-amine |
| InChl Key | DCXVYXPVNSMWPG-IAGOWNOFSA-N |
| InChl Code | InChI=1S/C22H19FN6/c1-14-10-27-29-21(9-20(28-22(14)29)16-8-17(23)13-24-11-16)25-7-6-15-12-26-19-5-3-2-4-18(15)19/h2-5,8-13,25-26H,6-7H2,1H3 |
| SMILES Code | CC1=C2N=C(C3=CC(F)=CN=C3)C=C(NCCC4=CNC5=C4C=CC=C5)N2N=C1 |
| References | 1) Luis Felipe Campesato et al., Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine, Nature Communications volume 11, Article number: 4011 (2020) |
More info
Novel potent and selective inhibitor of aryl hydrocarbon receptor (AHR) (IC50 of 22 nM in the human HepG2 DRE-luciferase reporter assay and 23 nM in the murine Hepa1 Cyp-luc assay)
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