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View larger PKUMDL-LC-101-D04
AT36935
CAS 2143896-83-5
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $57.80 | Total: $289.00 |
| 1 | 10 | $48.96 | Total: $489.60 |
| 1 | 25 | $41.48 | Total: $1,037.00 |
| 1 | 50 | $35.36 | Total: $1,768.00 |
| 1 | 100 | $30.60 | Total: $3,060.00 |
Data sheet
| Molecular Formula | C14H23ClN4O2S2 |
| Molecular Weight | 378.94 |
| CAS Numbers | 2143896-83-5 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cl.NCCNS(=O)(=O)c1ccc(NC(=S)NC2CCCC2)cc1 |
| References | Li C, et al. Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4. J Med Chem. 2019;62[1] 266-275. |
More info
PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of ferroptosis. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 ?M in a cell-free assay, and at a concentration of 61 ?M in wild-type, but not Gpx4--, mouse embryonic fibroblast (MEF) extracts.PKUMDL-LC-101-D04 (200 ?M) reduced cholesterol peroxide-induced MEF death.