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Steroid Hormone Receptors
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View larger Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $108.80 | Total: $544.00 |
| 1 | 10 | $92.16 | Total: $921.60 |
| 1 | 25 | $78.08 | Total: $1,952.00 |
| 1 | 50 | $66.56 | Total: $3,328.00 |
| 1 | 100 | $57.60 | Total: $5,760.00 |
Data sheet
| Molecular Formula | C28H28N2O3S |
| Molecular Weight | 472.6 |
| CAS Numbers | 849662-80-2 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(=O)(C1=C(SC=2C1=CC=C(O)C2)C3=CC=C(O)C=C3)C4=CC=C(C=C4)N5CCN(C(C)C)CC5 |
| References | Ning M, et al. Biological activities of a novel selective oestrogen receptor modulator derived from raloxifene [Y134]. Br J Pharmacol. 2007;150[1] 19-28. |
More info
Y134 is an estrogen receptor inhibitor that is selective and orally active, exhibiting strong antagonist activity against ER? and Er? with Ki of 0.09 nM and 11.31 nM, respectively. The selectivity of Y134 for ER? is 121.1 times higher than that for ER?. Y134 inhibited the proliferation of ER positive human breast cancer cells stimulated by estrogen.