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Steroid Hormone Receptors
- Protein Control Ligand
- Pathway Inhibitors
- Enzyme Inhibitors
- Kinase Inhibitors
- Protease
- Synthase
- p18
- p38
- p53
- p70
- p90
- Peptidase
- Carboxyl and Decarboxylases
- Ceramide Turnover Enzymes
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- Cyclic Nucleotide Turnover Enzymes
- Glycerophospholipid Turnover Enzymes
- Hydroxylases
- Ubiquitin-Activating Enzyme
- Adenosine Deaminase
- Clathrin
- Nuclease
- p68
- ACE
- COX
- DHFR
- Neprilysin
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- RAF
- RAS
- Reductase
- ROR
- Topoisomerase
- Transferase
- Protein Inhibitors
- Transporter Inhibitors
- Cell Inhibition
- Synthase
- Receptor Tyrosine Phosphatases (RTP)
- AChE
- Peptidase
- Autophagy
- Toll-Like Receptor (TLR)
- Enzyme Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- 5HT Receptors
- Adrenoceptor
- Angiotensin Receptor
- Cannabinoid Receptors
- CCK Receptors
- DA Receptors
- EAA Receptors
- Ghrelin Receptors
- GABA Receptors
- Histamine Receptors
- Leukotriene Receptors
- Metabotropic Glutamate Receptors
- Motilin Receptors
- Muscarinic Receptor
- Neuropeptide Receptors
- Opioid Receptors
- Orexin Receptors
- Orphan Receptors
- Prostanoid Receptors
- Proteinase-Activated Receptors
- Purinergic Receptors
- Ryanodine receptor
- Sigma Receptors
- Thrombin Receptor
- Vaniloid Receptor
- VIP and PACAP Receptors
- Neurotensin Receptors
- Urotensin Receptor
- Imidazoline receptor
- SMO Receptors
- Apelin Receptor
- β-arrestin/β2-adaptin
- KDM4
- Glucocorticoid Receptor
- Laminin Receptor
- AHR
- Amylin Receptor
- Bombesin Receptor
- Bradykinin Receptor
- CFTR
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- Ephrin Receptor
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- Biomarkers and Buffer Solutions
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- Molecular Glues
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- SARS-CoV
View larger Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $19.80 | Total: $1,980.00 |
| 1 | 50 | $22.88 | Total: $1,144.00 |
| 1 | 25 | $26.84 | Total: $671.00 |
| 1 | 10 | $31.68 | Total: $316.80 |
| 1 | 5 | $37.40 | Total: $187.00 |
Data sheet
| Molecular Formula | C22H23ClN6O2 |
| Molecular Weight | 438.91 |
| CAS Numbers | 2677786-61-5 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CCc1cc(Nc2nc(NCc3ccc(Cl)cc3OC)nc3cccc(OC)c23)n[nH]1 |
| References | Uehling DE, et al. Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 [GRK6] for the Treatment of Multiple Myeloma [published correction appears in J Med Chem. 2022 Jan 13;65[1] 886-887]. J Med Chem. 2021;64[15] 11129-11147. |
More info
GRK6-IN-1 (compound 18) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM, and has potential for study in multiple myeloma.