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View larger BMS-903452
AT67791
CAS 1339944-47-6
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $111.35 | Total: $556.75 |
| 1 | 10 | $94.32 | Total: $943.20 |
| 1 | 25 | $79.91 | Total: $1,997.75 |
| 1 | 50 | $68.12 | Total: $3,406.00 |
| 1 | 100 | $58.95 | Total: $5,895.00 |
Data sheet
| Molecular Formula | C21H19Cl2FN4O4S |
| Molecular Weight | 513.37 |
| CAS Numbers | 1339944-47-6 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O=C1N(C=C(Cl)C(OC2CCN(CC2)C=3N=CC(Cl)=CN3)=C1)C4=C(F)C=C(S(C)(=O)=O)C=C4 |
| References | Wacker DA, et al. Discovery of 5-chloro-4-[[1-[5-chloropyrimidin-2-yl]piperidin-4-yl]oxy]-1-[2-fluoro-4-[methylsulfonyl]phenyl]pyridin-2[1H]-one [BMS-903452], an antidiabetic clinical candidate targeting GPR119. J Med Chem. 2014;57[18] 7499-7508. |
More info
BMS-903452 is a potent and selective GPR119 agonist with an EC50 of 14 nM, indicated for the treatment of acute and chronic rodent diabetes. GPR119 is mainly expressed in pancreatic b cells and gastrointestinal endocrine cells. BMS-903452 shows no significant inhibitory effect on 9 cytochrome P450 enzymes (IC50 > 40 ?M), does not activate PXR (EC50 > 50 ?M), and is not toxic to liver (HEPG2) cell lines.