Synthase

GW274150 View larger

GW274150

AT11518L

CAS 210354-22-6

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$27.00

$27.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $12.15 Total: $1,215.00
150 $14.04 Total: $702.00
125 $16.47 Total: $411.75
110 $19.44 Total: $194.40
15 $22.95 Total: $114.75

Data sheet

Molecular FormulaC8H17N3O2S
Molecular Weight219.3
CAS Numbers210354-22-6
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeC([C@@H](C(O)=O)N)CSCCNC(C)=N
ReferencesAlderton WK, et al. GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo.Br J Pharmacol. 2005 Jun;145[3] 301-12.

More info

GW274150 is an orally active, selective and potent dual inhibitor of NADPH-dependent human nitric oxide synthase (iNOS) (Kd=40 nM) and rat inducible nitric oxide synthase (iNOS).GW274150 has a low activity against endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) in humans and rats. GW274150 showed protective effects in an inflammatory model of acute lung injury.