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View larger Cot inhibitor-2
AT10866
CAS 915363-56-3
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $67.15 | Total: $335.75 |
| 1 | 10 | $56.88 | Total: $568.80 |
| 1 | 25 | $48.19 | Total: $1,204.75 |
| 1 | 50 | $41.08 | Total: $2,054.00 |
| 1 | 100 | $35.55 | Total: $3,555.00 |
Data sheet
| Molecular Formula | C26H25Cl2FN8 |
| Molecular Weight | 539.43 |
| CAS Numbers | 915363-56-3 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CCN1CCC(CC1)n1cc(CNc2cc(Cl)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)nn1 |
| References | Wu J, et al. Selective inhibitors of tumor progression loci-2 [Tpl2] kinase with potent inhibition of TNF-alpha production in human whole blood. Bioorg Med Chem Lett. 2009 ; 19[13] 3485-3488. |
More info
Cot inhibitor-2 is a cot (Tpl2MAP3K8) inhibitor (IC50: 1.6 nM) with potency, selectivity and oral activity. cot inhibitor-2 inhibits LPS-stimulated TNF-? production in human whole blood with an IC50 of 0.3 ?M.