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Transcription Factors
- Protein Control Ligand
- Pathway Inhibitors
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- Kinase Inhibitors
- Protease
- Synthase
- p18
- p38
- p53
- p70
- p90
- Peptidase
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- Ceramide Turnover Enzymes
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- Cyclic Nucleotide Turnover Enzymes
- Glycerophospholipid Turnover Enzymes
- Hydroxylases
- Ubiquitin-Activating Enzyme
- Adenosine Deaminase
- Clathrin
- Nuclease
- p68
- ACE
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- DHFR
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- RAF
- RAS
- Reductase
- ROR
- Topoisomerase
- Transferase
- Protein Inhibitors
- Transporter Inhibitors
- Cell Inhibition
- Synthase
- Receptor Tyrosine Phosphatases (RTP)
- AChE
- Peptidase
- Autophagy
- Toll-Like Receptor (TLR)
- Enzyme Inhibitors
- Function Modulators
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- G Protein-Coupled Receptor Ligands
- 5HT Receptors
- Adrenoceptor
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- CCK Receptors
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- Ghrelin Receptors
- GABA Receptors
- Histamine Receptors
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- Metabotropic Glutamate Receptors
- Motilin Receptors
- Muscarinic Receptor
- Neuropeptide Receptors
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- Orphan Receptors
- Prostanoid Receptors
- Proteinase-Activated Receptors
- Purinergic Receptors
- Ryanodine receptor
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- Thrombin Receptor
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- VIP and PACAP Receptors
- Neurotensin Receptors
- Urotensin Receptor
- Imidazoline receptor
- SMO Receptors
- Apelin Receptor
- β-arrestin/β2-adaptin
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- Biomarkers and Buffer Solutions
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $48.15 | Total: $4,815.00 |
| 1 | 50 | $55.64 | Total: $2,782.00 |
| 1 | 25 | $65.27 | Total: $1,631.75 |
| 1 | 10 | $77.04 | Total: $770.40 |
| 1 | 5 | $90.95 | Total: $454.75 |
Data sheet
| Molecular Formula | C28H29N3O2 |
| Molecular Weight | 439.55 |
| CAS Numbers | 853138-65-5 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC(C)c1ccc(NC(=O)C(N(C)C(=O)Cc2c[nH]c3ccccc23)c2ccccc2)cc1 |
| References | Pedemonte N, et al. Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating. Mol Pharmacol. 2005 May;67[5] 1797-807. |
More info
PG01 is a potent CFTR Cl-channel potentiator, effective against ?F508 (Ka 0.3 ?M), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.22 ?M, 0.45 ?M and 1.94 ?M, respectively.PG01 increases ?F508-CFTR Cl- currents upon addition of forskolin. F508-CFTR Cl-current upon addition of Forskolin, correcting the gating defect of CFTR mutants.