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Transcription Factors
- Protein Control Ligand
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View larger Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $90.95 | Total: $454.75 |
| 1 | 10 | $77.04 | Total: $770.40 |
| 1 | 25 | $65.27 | Total: $1,631.75 |
| 1 | 50 | $55.64 | Total: $2,782.00 |
| 1 | 100 | $48.15 | Total: $4,815.00 |
Data sheet
| Molecular Formula | C28H29N3O2 |
| Molecular Weight | 439.55 |
| CAS Numbers | 853138-65-5 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC(C)c1ccc(NC(=O)C(N(C)C(=O)Cc2c[nH]c3ccccc23)c2ccccc2)cc1 |
| References | Pedemonte N, et al. Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating. Mol Pharmacol. 2005 May;67[5] 1797-807. |
More info
PG01 is a potent CFTR Cl-channel potentiator, effective against ?F508 (Ka 0.3 ?M), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.22 ?M, 0.45 ?M and 1.94 ?M, respectively.PG01 increases ?F508-CFTR Cl- currents upon addition of forskolin. F508-CFTR Cl-current upon addition of Forskolin, correcting the gating defect of CFTR mutants.