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View larger TD-198946
AOB37051
CAS 364762-86-7
Chemical Name: 1-Methyl-8-[4-(quinolin-2-ylmethoxy)phenoxy]-4,5-dihydrothieno[3,4-g]indazole-6-carboxamide
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $24.65 | Total: $123.25 |
| 1 | 10 | $20.88 | Total: $208.80 |
| 1 | 25 | $17.69 | Total: $442.25 |
| 1 | 50 | $15.08 | Total: $754.00 |
| 1 | 100 | $13.05 | Total: $1,305.00 |
Data sheet
| Molecular Formula | C27H22N4O3S |
| Molecular Weight | 482.55 |
| CAS Numbers | 364762-86-7 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | TD-198946; TD 198946; TD198946. |
| IUPAC/Chemical Name | 1-Methyl-8-[4-(quinolin-2-ylmethoxy)phenoxy]-4,5-dihydrothieno[3,4-g]indazole-6-carboxamide |
| InChl Key | QGAMAWMLTUNPAB-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C27H22N4O3S/c1-31-24-17(14-29-31)7-13-21-23(24)27(35-25(21)26(28)32)34-20-11-9-19(10-12-20)33-15-18-8-6-16-4-2-3-5-22(16)30-18/h2-6,8-12,14H,7,13,15H2,1H3,(H2,28,32) |
| SMILES Code | O=C(C1=C2CCC3=C(N(C)N=C3)C2=C(OC4=CC=C(OCC5=NC6=CC=CC=C6C=C5)C=C4)S1)N |
| References | 1) Yano F, et al., Disease-modifying effects of TD-198946 on progressed osteoarthritis in a mouse model. Ann Rheum Dis. 2014 Nov;73(11):2062-4. doi: 10.1136/annrheumdis-2014-205672. Epub 2014 Aug 18. PubMed PMID: 25135252.2) Yano F, et al., Cell-sheet technology combined with a thienoindazole derivative small compound TD-198946 for cartilage regeneration. Biomaterials. 2013 Jul;34(22):5581-7. doi: 10.1016/j.biomaterials.2013.04.008. Epub 2013 Apr 24. PubMed PMID: 23623324 |
More info
Novel ckass of disease-modifying osteoarthritis drug (DMOAD), strongly inducing chondrogenic differentiation without promoting hypertrophy in cell and metatarsal organ cultures