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Rokitamycin

AOB9356

CAS: 74014-51-0

 

Chemical Name: Ricamycin; Propionylleucomycin; [(2S,3S,4R,6S)-6-[(2R,3S,4R,5R,6S)-6-[[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4,10-Dihydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-2,4-dimethyl-4-propanoyloxyoxan-3-yl] butanoate

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QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $17.85 Total: $89.25
110 $15.12 Total: $151.20
125 $12.81 Total: $320.25
150 $10.92 Total: $546.00
1100 $9.45 Total: $945.00

Data sheet

Molecular FormulaC42H68NO16
Molecular Weight842.99
CAS Numbers74014-51-0
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO and Water
Purity98% by HPLC
SynonymRokitamycin
IUPAC/Chemical Name3-((4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-(butyryloxy)-6-(((2S,3R,4R,5S,6R)-5-(((2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-3-yl)propanoate
InChl KeyWMPXTDMRSHZXNQ-TYEDIMFNSA-M
InChl CodeInChI=1S/C42H69NO16/c1-10-14-31(48)57-37-28(17-18-30(46)47)40(51)54-24(3)15-12-11-13-16-29(45)23(2)21-27(19-20-44)36(38(37)53-9)59-41-34(49)33(43(7)8)35(25(4)56-41)58-32-22-42(6,52)39(50)26(5)55-32/h11-13,16,20,23-29,32-39,41,45,49-50,52H,10,14-15,17-19,21-22H2,1-9H3,(H,46,47)/p-1/b12-11+,16-13+/t23-,24-,25-,26+,27+,28?,29+,32+,33-,34-,35-,36+,37-,38+,39+,41+,42-/m1/s1
SMILES CodeO[C@H]([C@@H](N(C)C)[C@@H]([C@@H](C)O1)O[C@H]2C[C@@]([C@H]([C@H](C)O2)O)(C)O)[C@@H]1O[C@@H]3[C@H](OC)[C@H](OC(CCC)=O)C(CCC([O-])=O)C(O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)=O
References1) Kim JH, Lee YJ, Sohn HJ, Song KJ, Kwon D, Kwon MH, Im KI, Shin HJ. Therapeutic effect of rokitamycin in vitro and on experimental meningoencephalitis due to Naegleria fowleri. Int J Antimicrob Agents. 2008 Nov;32(5):411-7. doi: 10.1016/j.ijantimicag.2008.05.018. Epub 2008 Aug 30. PubMed PMID: 18762406.

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Macrolide antibiotic, inducing DNA fragmentation and caspase activation, resembling the progression of apoptosis, reducing the mitochondrial transmembrane potential and released cytochrome c from mitochondria to the cytosol

 

References:

https://pubmed.ncbi.nlm.nih.gov/?term=Rokitamycin+&sort=date