Votage-Gated Ion Channel Blockers

PF-4840154 View larger

PF-4840154

AT4385

CAS 1332708-14-1

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$94.00

$94.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $42.30 Total: $4,230.00
150 $48.88 Total: $2,444.00
125 $57.34 Total: $1,433.50
110 $67.68 Total: $676.80
15 $79.90 Total: $399.50

Data sheet

Molecular FormulaC26H38N6O2
Molecular Weight466.62
CAS Numbers1332708-14-1
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCC(C)CNc1nc(ncc1C(=O)NCc1ccccc1)N1CCN(CC2CCCOC2)CC1
ReferencesRyckmans T,etal.Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel.Bioorg Med Chem Lett. 2011 Aug 15;21[16] 4857-9.

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PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel, eliciting TrpA1-mediated nocifensive behavior in mouse, with EC50 values of 97 nM and 23 nM for [rTrpA1] and [hTrpA1], respectively.