Votage-Gated Ion Channel Blockers

Phenytoin View larger

Phenytoin

AT0939

CAS 57-41-0

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Data sheet

Molecular FormulaC15H12N2O2
Molecular Weight252.27
CAS Numbers57-41-0
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeO=C1NC(=O)C(N1)(c1ccccc1)c1ccccc1
ReferencesOwoeye O, et al. J Diet Suppl. 2015 Mar;12[1] 105-17.

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Phenytoin (5,5-Diphenylhydantoin) is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. It potentially acts by promoting sodium efflux from neurons in the motor cortex, reducing post-tetanic potentiation at synapses. This prevents cortical seizure foci from spreading to adjacent areas and stabilizes the threshold against hyperexcitability. Additionally, it appears to reduce muscle spindle sensitivity to stretch, causing muscle relaxation.