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View larger ITH12575
AOBS1947
CAS No: 1802013-08-6
Chemical Name: 7-chloro-5-(2-isopropylphenyl)-1,5-dihydrobenzo[e][1,4]thiazepin-2(3H)-one
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $21.25 | Total: $106.25 |
| 1 | 10 | $18.00 | Total: $180.00 |
| 1 | 25 | $15.25 | Total: $381.25 |
| 1 | 50 | $13.00 | Total: $650.00 |
| 1 | 100 | $11.25 | Total: $1,125.00 |
Data sheet
| Molecular Formula | C18H18ClNOS |
| Molecular Weight | 331.86 |
| CAS Numbers | 1802013-08-6 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | 2 mg/mL in DMSO |
| Purity | 98% by HPLC |
More info
A potent and selective inhibitor of mitochondrial Na+/Ca2+ exchanger mNCX with neuroprotective activity. It was shown to reduce Ca2+ efflux from the mitochondria to the cytosol with an EC50 value of 690 nM and was shown to protect against Ca2+ overload and mitigated the neuronal damage in a model of oxidative stress. At higher concentrations ITH12575 also reduced Ca2+ influx through CALHM1, a Ca2+ channel that plays a key role in the neuronal electrical activity