Activators

SSTC3 View larger

SSTC3

AOB31804

CAS: 242422-09-8

 

Chemical Name: 4-(N-Methyl-N-(4-(trifluoromethyl)phenyl)sulfamoyl)-N-(4-(pyridin-2-yl)thiazol-2-yl)benzamide

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$37.50

$37.50 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $16.88 Total: $1,687.50
150 $19.50 Total: $975.00
125 $22.88 Total: $571.88
110 $27.00 Total: $270.00
15 $31.88 Total: $159.38

Data sheet

Molecular FormulaC23H17BF3N4O3S2
Molecular Weight518.53
CAS Numbers242422-09-8
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymSSTC-3; SSTC 3; SSTC3
IUPAC/Chemical Name4-(N-Methyl-N-(4-(trifluoromethyl)phenyl)sulfamoyl)-N-(4-(pyridin-2-yl)thiazol-2-yl)benzamide
InChl KeyHSFAATUFWDDUGW-UHFFFAOYSA-N
InChl Code InChI=1S/C23H17F3N4O3S2/c1-30(17-9-7-16(8-10-17)23(24,25)26)35(32,33)18-11-5-15(6-12-18)21(31)29-22-28-20(14-34-22)19-4-2-3-13-27-19/h2-14H,1H3,(H,28,29,31)
SMILES CodeO=C(NC1=NC(C2=NC=CC=C2)=CS1)C3=CC=C(S(=O)(N(C)C4=CC=C(C(F)(F)F)C=C4)=O)C=C3
ReferencesLi B, Orton D, Neitzel LR, Astudillo L, Shen C, Long J, Chen X, Kirkbride KC, Doundoulakis T, Guerra ML, Zaias J, Fei DL, Rodriguez-Blanco J, Thorne C, Wang Z, Jin K, Nguyen DM, Sands LR, Marchetti F, Abreu MT, Cobb MH, Capobianco AJ, Lee E, Robbins DJ. Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors. Sci Signal. 2017 Jun 27;10(485). pii: eaak9916

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Novel potent activator of the kinase CK1alpha, suppressing WNT activity in CRC cell lines, preventing tumor growth, and increased survival in mouse models of primary and metastatic CRC

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