Apoptosis

FKGK18 View larger

FKGK18

AOB4846

CAS No: 1071001-09-6

 

Chemical Name: 1,1,1-Trifluoro-6-(2-naphthalenyl)-2-hexanone

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$22.00

$22.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

Quantity (mg or Unit)Unit Price ($/mg or $/Unit)Final Price
100 $9.90 Total: $990.00
50 $11.44 Total: $572.00
25 $13.42 Total: $335.50
10 $15.84 Total: $158.40
5 $18.70 Total: $93.50

Data sheet

Molecular FormulaC16H15F3O
Molecular Weight280.28
CAS Numbers1071001-09-6
SynonymFKGK18; FKGK-18; FKGK 18
IUPAC/Chemical Name1,1,1-trifluoro-6-(2-naphthalenyl)-2-hexanone
InChl KeyVCWWTQMRNJSJGC-UHFFFAOYSA-N
InChl CodeInChI=1S/C16H15F3O/c17-16(18,19)15(20)8-4-1-5-12-9-10-13-6-2-3-7-14(13)11-12/h2-3,6-7,9-11H,1,4-5,8H2
SMILES CodeO=C(C(F)(F)F)CCCCC1=CC2=CC=CC=C2C=C1
References1) Kokotos, G., et al. Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J. Med. Chem. 53(9), 3602-3610 (2010).

2) Ali, T., et al. Characterization of FKGK18 as inhibitor of group VIA Ca2+-independent phospholipase A2 (iPLA2β): Candidate drug for preventing β-cell apoptosis and diabetes. PLoS One 8(8):e71748, (2013).

3) Bone, R.N., et al. Inhibition of Ca2+-independent phospholipase A2β (iPLA2β) ameliorates islet infiltration and incidence of diabetes in NOD mice. Diabetes 64(2), 541-554 (2015).

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Novel Inhibitor of Group VIA Ca(2+)-Independent Phospholipase A2 (iPLA2β) for Preventing Beta-Cell Apoptosis and Diabetes

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