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Calcium Channel
- Protein Control Ligand
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GSK-7975A
AOB4124
AOBIOUS launched this product in 2013
CITATIONS - Publications That Use AOBIOUS Product
1) Journal Of Neuroscience, 36(11): 3184-3198 (2016)
4) BIOCHEM BIOPH RES CO (2017)
5) ENDOCRINOLOGY 159(2):647-664 (2018)
Molarity Calculation Cart®
HOW TO ORDER
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $6.75 | Total: $675.00 |
| 1 | 50 | $7.80 | Total: $390.00 |
| 1 | 25 | $9.15 | Total: $228.75 |
| 1 | 10 | $10.80 | Total: $108.00 |
| 1 | 5 | $12.75 | Total: $63.75 |
Data sheet
| Molecular Formula | C18H12F5N3O2 |
| Molecular Weight | 397.30 |
| CAS Numbers | 1253186-56-9 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | GSK-7975A; GSK 7975A; GSK7975A; GSK-7975; GSK 7975; GSK7975 |
| IUPAC/Chemical Name | 2,6-difluoro-N-(1-(4-hydroxy-2-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamide |
| InChl Key | CPYTVBALBFSXSH-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C18H12F5N3O2/c19-13-2-1-3-14(20)16(13)17(28)24-15-6-7-26(25-15)9-10-4-5-11(27)8-12(10)18(21,22)23/h1-8,27H,9H2,(H,24,25,28) |
| SMILES Code | O=C(NC1=NN(CC2=CC=C(O)C=C2C(F)(F)F)C=C1)C3=C(F)C=CC=C3F |
| References | 1) Duffy SM, Ashmole I, Smallwood DT, Leyland ML, Bradding P. Orai/CRACM1 and KCa3.1 ion channels interact in the human lung mast cell plasma membrane. Cell Commun Signal. 2015 Jul 16;13:32. 2) Wen L, etc Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models. Gastroenterology. 2015 Aug;149(2):481-92.e7. 3) Voronina S, Collier D, Chvanov M, Middlehurst B, Beckett AJ, Prior IA, Criddle DN, Begg M, Mikoshiba K, Sutton R, Tepikin AV. The role of Ca2+ influx in endocytic vacuole formation in pancreatic acinar cells. Biochem J. 2015 Feb 1;465(3):405-12 |
More info
An potent and orally active inhibitors of ORAI1 (calcium release-activated calcium modulator )
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