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> Function Modulators>Votage-Gated Ion Channel Blockers>Calcium Channel>AMG-416 (Velcalcetide)

Calcium Channel

AMG-416 (Velcalcetide) View larger

AMG-416 (Velcalcetide)

AOB37357

CAS No: 1262780-97-1

 

Chemical Name: Etelcalcetide HCl; AMG-416; H-Cys(1)-OH.Ac-D-Cys(1)-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2 HCl

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $67.15 Total: $335.75
110 $56.88 Total: $568.80
125 $48.19 Total: $1,204.75
150 $41.08 Total: $2,054.00
1100 $35.55 Total: $3,555.00

Data sheet

Molecular FormulaC38H78Cl5N21O10S2
Molecular Weight1230.55
CAS Numbers1262780-97-1 (Free Base)
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
InChl KeyANIAZGVDEUQPRI-ZJQCGQFWSA-N
InChl CodeInChI=1S/C38H73N21O10S2/c1-18(28(62)56-22(27(40)61)8-4-12-49-35(41)42)53-30(64)23(9-5-13-50-36(43)44)58-32(66)25(11-7-15-52-38(47)48)59-31(65)24(10-6-14-51-37(45)46)57-29(63)19(2)54-33(67)26(55-20(3)60)17-71-70-16-21(39)34(68)69/h18-19,21-26H,4-17,39H2,1-3H3,(H2,40,61)(H,53,64)(H,54,67)(H,55,60)(H,56,62)(H,57,63)(H,58,66)(H,59,65)(H,68,69)(H4,41,42,49)(H4,43,44,50)(H4,45,46,51)(H4,47,48,52)/t18-,19-,21+,22-,23-,24-,25-,26-/m1/s1
SMILES CodeO=C([C@H](NC([C@H](NC([C@H](NC([C@@H](CSSC[C@@H](C(O)=O)N)NC(C)=O)=O)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)N[C@@H](C(N[C@@H](C(N[C@H](CCCNC(N)=N)C(N)=O)=O)C)=O)CCCNC(N)=N
ReferencesHarada, K., Fujioka, A., Konno, M., et al. Pharmacology of Parsabiv® (etelcalcetide, ONO-5163/AMG 416), a novel allosteric modulator of the calcium-sensing receptor, for secondary hyperparathyroidism in hemodialysis patients. Eur. J. Pharmacol. 842, 139-145 (2019).

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