Cell Inhibition

RO2959 Hydrochloride View larger

RO2959 Hydrochloride

AOB3633

CAS No: 1219927-22-6 and 1220022-06-9 (Free Base)

Chemical Name: 2,6-Difluoro-N-{5-[4-methyl-1-(5-methyl-thiazol-2-yl)-1,2,5,6-tetrahydro-pyridin-3-yl]-pyrazin-2-yl}-benzamide Hydrochloride

AOBIOUS launched this product in 2014

CITATIONS - Publications That Use AOBIOUS Product

1) J Biol Chem. 2017 May 19; 292(20): 8158–8173.

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Molarity Calculation Cart®

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$36.50

$36.50 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $16.43 Total: $1,642.50
150 $18.98 Total: $949.00
125 $22.27 Total: $556.63
110 $26.28 Total: $262.80
15 $31.03 Total: $155.13

Data sheet

Molecular FormulaC21H20ClF2N5OS
Molecular Weight463.93
CAS Numbers1219927-22-6 and 1220022-06-9 (Free Base)
SynonymRO2959 Hydrochloride; RO2959 HCl; RO2959; RO 2959; RO-2959
IUPAC/Chemical Name2,6-Difluoro-N-{5-[4-methyl-1-(5-methyl-thiazol-2-yl)-1,2,5,6-tetrahydro-pyridin-3-yl]-pyrazin-2-yl}-benzamide Hydrochloride
InChl KeyGMLSDODALBRLPE-UHFFFAOYSA-N
InChl Code InChI=1S/C21H19F2N5OS.ClH/c1-12-6-7-28(21-26-8-13(2)30-21)11-14(12)17-9-25-18(10-24-17)27-20(29)19-15(22)4-3-5-16(19)23;/h3-5,8-10H,6-7,11H2,1-2H3,(H,25,27,29);1H
SMILES CodeO=C(NC1=NC=C(C2=C(C)CCN(C3=NC=C(C)S3)C2)N=C1)C4=C(F)C=CC=C4F.[H]Cl
References1) Zheng C, et al. Gastrodin Inhibits Store-Operated Ca(2+) Entry and Alleviates Cardiac Hypertrophy. Front Pharmacol. 2017 Apr 25;8:222. doi: 10.3389/fphar.2017.00222. eCollection 2017. PubMed PMID: 28487655

2) Chen G, et al. Characterization of a novel CRAC inhibitor that potently blocks human T cell activation and effector functions. Mol Immunol. 2013 Jul;54(3-4):355-67. doi: 10.1016/j.molimm.2012.12.011. Epub 2013 Jan 26.

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Novel, potent and selective CRAC current inhibitor that potently blocks human T cell activation and effector functions

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