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RO2959 Hydrochloride
AOB3633
CAS No: 1219927-22-6 and 1220022-06-9 (Free Base)
Chemical Name: 2,6-Difluoro-N-{5-[4-methyl-1-(5-methyl-thiazol-2-yl)-1,2,5,6-tetrahydro-pyridin-3-yl]-pyrazin-2-yl}-benzamide Hydrochloride
AOBIOUS launched this product in 2014
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| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $16.43 | Total: $1,642.50 |
| 1 | 50 | $18.98 | Total: $949.00 |
| 1 | 25 | $22.27 | Total: $556.63 |
| 1 | 10 | $26.28 | Total: $262.80 |
| 1 | 5 | $31.03 | Total: $155.13 |
Data sheet
| Molecular Formula | C21H20ClF2N5OS |
| Molecular Weight | 463.93 |
| CAS Numbers | 1219927-22-6 and 1220022-06-9 (Free Base) |
| Synonym | RO2959 Hydrochloride; RO2959 HCl; RO2959; RO 2959; RO-2959 |
| IUPAC/Chemical Name | 2,6-Difluoro-N-{5-[4-methyl-1-(5-methyl-thiazol-2-yl)-1,2,5,6-tetrahydro-pyridin-3-yl]-pyrazin-2-yl}-benzamide Hydrochloride |
| InChl Key | GMLSDODALBRLPE-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C21H19F2N5OS.ClH/c1-12-6-7-28(21-26-8-13(2)30-21)11-14(12)17-9-25-18(10-24-17)27-20(29)19-15(22)4-3-5-16(19)23;/h3-5,8-10H,6-7,11H2,1-2H3,(H,25,27,29);1H |
| SMILES Code | O=C(NC1=NC=C(C2=C(C)CCN(C3=NC=C(C)S3)C2)N=C1)C4=C(F)C=CC=C4F.[H]Cl |
| References | 1) Zheng C, et al. Gastrodin Inhibits Store-Operated Ca(2+) Entry and Alleviates Cardiac Hypertrophy. Front Pharmacol. 2017 Apr 25;8:222. doi: 10.3389/fphar.2017.00222. eCollection 2017. PubMed PMID: 28487655 2) Chen G, et al. Characterization of a novel CRAC inhibitor that potently blocks human T cell activation and effector functions. Mol Immunol. 2013 Jul;54(3-4):355-67. doi: 10.1016/j.molimm.2012.12.011. Epub 2013 Jan 26. |
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Novel, potent and selective CRAC current inhibitor that potently blocks human T cell activation and effector functions
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