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GI254023X

Cat No: AOB3611

Condition

CAS No: 260264-93-5

AOBIOUS launched this product in 2013

Citation (Publications used AOBIOUS products):

1) Journal of Medical Virology Received 9 October2016; Revised 5 July2017; Accepted 11 July 2017

2) Front Cell Dev Biol. 2021; 9: 661462.

3) Cancers (Basel). 2021 May; 13(9): 2039

4) Sci Rep. 2020; 10: 14839.

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Quantity Discount Table - Order More To Get More Price Discount

Quantity	mg	Unit Price ($/mg or $/Unit)	Final Price
1	100	$9.45	Total: $945.00
1	50	$10.92	Total: $546.00
1	25	$12.81	Total: $320.25
1	10	$15.12	Total: $151.20
1	5	$17.85	Total: $89.25

Data sheet

Molecular Formula	C21H33N3O4
Molecular Weight	391.50
CAS Numbers	260264-93-5
Storage Condition	0°C (short term), -20°C (long term), desiccated
Solubility	DMSO
Purity	98% by HPLC
Synonym	GI254023X; GI 254023X; GI-254023X;GI4023; GI-4023; GI 4023
IUPAC/Chemical Name	(2R)-N-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]-propyl]-2-[(1S)-1-[formyl(hydroxy)amino]ethyl]-5-phenylpentanamide
InChl Key	GHVMTHKJUAOZJP-CGTJXYLNSA-N
InChl Code	InChI=1S/C21H33N3O4/c1-15(24(28)14-25)17(13-9-12-16-10-7-6-8-11-16)19(26)23-18(20(27)22-5)21(2,3)4/h6-8,10-11,14-15,17-18,28H,9,12-13H2,1-5H3,(H,22,27)(H,23,26)/t15-,17+,18+/m0/s1
SMILES Code	O=C(N[C@H](C(NC)=O)C(C)(C)C)[C@@H]([C@@H](N(C=O)O)C)CCCC1=CC=CC=C1

More info

ADAM10-specific metalloprotease inhibitor, preventing Hla-mediated injury

References:

1) Hundhausen et al (2003) The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediates cell-cell adhesion. Blood 102 1186. PMID: 12714508.

2) Ludwig et al (2005) Metalloprotease inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules. Comb.Chem.High Throughput Screen. 8 161. PMID: 15777180.

3) Moss et al (2007) The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events. J.Biol.Chem. 282 35712. PMID: 17895248.

4) Inoshima et al (2011) A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice. Nat.Med. 17 1310. PMID: 21926978.