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GBT440 (Voxelotor)
AOB8991
CAS: 1446321-46-5
Chemical Name: Voxelotor; GTx-011; 2-Hydroxy-6-[2-(2-isopropyl-2H-pyrazol-3-yl)-pyridin-3-ylmethoxy]-benzaldehyde
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $4.05 | Total: $405.00 |
| 1 | 50 | $4.68 | Total: $234.00 |
| 1 | 25 | $5.49 | Total: $137.25 |
| 1 | 10 | $6.48 | Total: $64.80 |
| 1 | 5 | $7.65 | Total: $38.25 |
Data sheet
| Molecular Formula | C19H19N3O3 |
| Molecular Weight | 337.37 |
| CAS Numbers | 1446321-46-5 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 2-hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]-benzaldehyde |
| InChl Key | FWCVZAQENIZVMY-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C19H19N3O3/c1-13(2)22-16(8-10-21-22)19-14(5-4-9-20-19)12-25-18-7-3-6-17(24)15(18)11-23/h3-11,13,24H,12H2,1-2H3 |
| SMILES Code | OC1=C(C=O)C(OCC2=CC=CN=C2C3=CC=NN3C(C)C)=CC=C1 |
| References | 1) Oksenberg, D., Dufu, K., Patel, M.P., et al. GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease. Br. J. Haematol. 175(1), 141-153 (2016). 2) Dufu, K., Lehrer-Graiwer, J., Ramos, E., et al. GBT440 inhibits sickling of sickle cell trait blood under in vitro conditions mimicking strenuous exercise. Hematol. Rep. 8:6637, 37-41 (2016). |
More info
A modulator of sickle hemoglobin (HbS) which can be used in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
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