Cell Inhibition

Protein Control Ligand
Pathway Inhibitors
- Enzyme Inhibitors
- Protein Inhibitors
- Transporter Inhibitors
  - ATPases
- Cell Inhibition
- Synthase
- Receptor Tyrosine Phosphatases (RTP)
Function Modulators
- Potentiators
- Allosteric
- Votage-Gated Ion Channel Blockers
- Major Facilitator Superfamily (MFS) Transporters
- Ligand-Gated Ion Channels
- Aquaporins
- Chlorine Channels
- Connexins and Pannexins
- KCC2 - K-Cl co-transporter
Activators
- Receptor Activators
- Inducer
- Openers
- Potassium Channel
G Protein-Coupled Receptor Ligands
- 5HT Receptors
- Adrenoceptor
- Angiotensin Receptor
- Cannabinoid Receptors
- CCK Receptors
- DA Receptors
- EAA Receptors
- Ghrelin Receptors
- GABA Receptors
- Histamine Receptors
- Leukotriene Receptors
- Metabotropic Glutamate Receptors
- Motilin Receptors
- Muscarinic Receptor
- Neuropeptide Receptors
- Opioid Receptors
- Orexin Receptors
- Orphan Receptors
- Prostanoid Receptors
- Proteinase-Activated Receptors
- Purinergic Receptors
- Ryanodine receptor
- Sigma Receptors
- Thrombin Receptor
- Vaniloid Receptor
- VIP and PACAP Receptors
- Neurotensin Receptors
- Urotensin Receptor
- Imidazoline receptor
- SMO Receptors
- Apelin Receptor
- β-arrestin/β2-adaptin
- KDM4
- Glucocorticoid Receptor
- Laminin Receptor
Nuclear Receptor Ligands
- Retinoic Acid, X and Orphans Receptors
- Rev-Erb Receptors
- Hepatocyte Nuclear Factors Receptors
- COUP-TF Like Receptors
- Growth Factors Receptors
- Steroid Hormone Receptors
- DAX-Like Receptors
- Vitamin Related Receptors
- PPARs
- DNA Polymerase
GDNF Receptors
TNF Receptors
Transcription Factors
Chemokines
- CXCR-2
- CXCR-3
- CXCR-4
- CXCR-7
Cytokine Receptors
- IL Receptors
- Interferon Receptors
- Integrins
- Toll-Like Receptors
- NOD-Like Receptors
Biomarkers and Buffer Solutions
- Universal DNA Markers
- Biological Buffers
- Biomarker
Molecular Probes
- Fluorescence Probes
- Chelating Agents
- Luminescent Probes
- Optical Probes
Stem Cell Research
- Reporter of Gene Expression
- CiPSC Cocktail
  - TSPC - CiPSC Cocktail
  - VC6TF - CiPSC Cocktail
Alzheimer's Disease
Apoptosis
Cancer Research
Epigenetics
Metabolites
PET/SPECT Imaging Precursors
Customized Screening Library
- Target Diversified Drug Like Small Molecule Library
- Target Focused Small Drug Like Molecule Library
Ultra Pure Pharmacological Standard
Tissue Microarray (TMA)
- Bladder
- Brain
- Breast
- Cervix
- Colon
- Digestive Sytem
- Esophagus
- Glucose Test Strips
- Kidney
- Large Intestine
- Liver
- Lung
- Lymphoma
- Multiple Organ
- Multiple Organ IFetus)
- Pancreas
- Prostate
- Rectum
- Reproductive System
- Stomach
- Thyroid
- Urological Sytem
Proteins and Antibodies
- Proteins and Enzymes
  - Cytokines and Chemokines
- Antibodies and Kits
  - RABBIT POLYCLONAL
  - RABBIT MONOCLONAL
- Protein Digestion Sufactant
- Cell Culture
Primary Cells
ELISA KIT
Natural Products
Lab Equipments
Humanized Mice for PDX Platform
Rare Chemicals
Custom Synthesis

View larger

SIRT6-IN-5

Cat No: AOB33587

Condition

CAS No: 891002-11-2

Chemical Name: SIRT6 inhibitor-5; 5-(4-(Furan-2-carboxamido)benzamido)-2-hydroxybenzoic acid

More details

Print Quotation

Molarity Calculation Cart^®

HOW TO ORDER

Quantity Discount Table - Order More To Get More Price Discount

Quantity	mg	Unit Price ($/mg or $/Unit)	Final Price
1	100	$12.15	Total: $1,215.00
1	50	$14.04	Total: $702.00
1	25	$16.47	Total: $411.75
1	10	$19.44	Total: $194.40
1	5	$22.95	Total: $114.75

Data sheet

Molecular Formula	C19H14N2O6
Molecular Weight	366.32
CAS Numbers	891002-11-2
Storage Condition	0°C (short term), -20°C (long term), desiccated
Solubility	DMSO
Purity	98% by HPLC
InChl Key	WCJCTRHTVZUWSD-UHFFFAOYSA-N

More info

Novel inhibitor of SIRT6, sensitizing pancreatic cancer cells to gemcitabine

REFERENCES

1) Damonte P, Sociali G, Parenti MD, Soncini D, Bauer I, Boero S, Grozio A, Holtey MV, Piacente F, Becherini P, Sanguineti R, Salis A, Damonte G, Cea M, Murone M, Poggi A, Nencioni A, Del Rio A, Bruzzone S. SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects. Bioorg Med Chem. 2017 Oct 15;25(20):5849-5858. doi: 10.1016/j.bmc.2017.09.023. Epub 2017 Sep 19. PubMed PMID: 28958848.

2) Wencel PL, Lukiw WJ, Strosznajder JB, Strosznajder RP. Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity. Mol Neurobiol. 2017 Jul 12. doi: 10.1007/s12035-017-0646-8. [Epub ahead of print] PubMed PMID: 28698968.

3) Shao J, Yang X, Liu T, Zhang T, Xie QR, Xia W. Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal damage. Protein Cell. 2016 Apr;7(4):281-90. doi: 10.1007/s13238-016-0257-6. Epub 2016 Mar 16. Erratum in: Protein Cell. 2017 Apr;8(4):313. PubMed PMID: 26983852; PubMed Central PMCID: PMC4818841.

4) Kokkonen P, Rahnasto-Rilla M, Mellini P, Jarho E, Lahtela-Kakkonen M, Kokkola T. Studying SIRT6 regulation using H3K56 based substrate and small molecules. Eur J Pharm Sci. 2014 Oct 15;63:71-6. doi: 10.1016/j.ejps.2014.06.015. Epub 2014 Jul 6. PubMed PMID: 25004411.