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SIRT6-IN-5

Cat No: AOB33587

Condition

CAS No: 891002-11-2

Chemical Name: SIRT6 inhibitor-5; 5-(4-(Furan-2-carboxamido)benzamido)-2-hydroxybenzoic acid

More details

983 Item Items

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Quantity Discount Table - Order More To Get More Price Discount

Quantity	mg	Unit Price ($/mg or $/Unit)	Final Price
1	5	$22.95	Total: $114.75
1	10	$19.44	Total: $194.40
1	25	$16.47	Total: $411.75
1	50	$14.04	Total: $702.00
1	100	$12.15	Total: $1,215.00

Data sheet

Molecular Formula	C19H14N2O6
Molecular Weight	366.32
CAS Numbers	891002-11-2
Storage Condition	0°C (short term), -20°C (long term), desiccated
Solubility	DMSO
Purity	98% by HPLC
InChl Key	WCJCTRHTVZUWSD-UHFFFAOYSA-N

More info

Novel inhibitor of SIRT6, sensitizing pancreatic cancer cells to gemcitabine

REFERENCES

1) Damonte P, Sociali G, Parenti MD, Soncini D, Bauer I, Boero S, Grozio A, Holtey MV, Piacente F, Becherini P, Sanguineti R, Salis A, Damonte G, Cea M, Murone M, Poggi A, Nencioni A, Del Rio A, Bruzzone S. SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects. Bioorg Med Chem. 2017 Oct 15;25(20):5849-5858. doi: 10.1016/j.bmc.2017.09.023. Epub 2017 Sep 19. PubMed PMID: 28958848.

2) Wencel PL, Lukiw WJ, Strosznajder JB, Strosznajder RP. Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity. Mol Neurobiol. 2017 Jul 12. doi: 10.1007/s12035-017-0646-8. [Epub ahead of print] PubMed PMID: 28698968.

3) Shao J, Yang X, Liu T, Zhang T, Xie QR, Xia W. Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal damage. Protein Cell. 2016 Apr;7(4):281-90. doi: 10.1007/s13238-016-0257-6. Epub 2016 Mar 16. Erratum in: Protein Cell. 2017 Apr;8(4):313. PubMed PMID: 26983852; PubMed Central PMCID: PMC4818841.

4) Kokkonen P, Rahnasto-Rilla M, Mellini P, Jarho E, Lahtela-Kakkonen M, Kokkola T. Studying SIRT6 regulation using H3K56 based substrate and small molecules. Eur J Pharm Sci. 2014 Oct 15;63:71-6. doi: 10.1016/j.ejps.2014.06.015. Epub 2014 Jul 6. PubMed PMID: 25004411.