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NPT200-11 (UCB0599)
AOB17316
CAS 2227057-23-8
Chemical Name: 1-(3-(1H-Indol-3-yl)propanoyl)-6-butyl-8-(piperidin-4-ylmethyl)hexahydro-4H-pyrazino[1,2-a]pyrimidine-4,7(6H)-dione
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| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $22.05 | Total: $2,205.00 |
| 1 | 50 | $25.48 | Total: $1,274.00 |
| 1 | 25 | $29.89 | Total: $747.25 |
| 1 | 10 | $35.28 | Total: $352.80 |
| 1 | 5 | $41.65 | Total: $208.25 |
Data sheet
| Molecular Formula | C28H39N5O3 |
| Molecular Weight | 493.65 |
| CAS Numbers | 2227057-23-8 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | NPT20011; NPT200 11; NPT200-11; UCB0599; UCB-0599; UCB 0599; |
| IUPAC/Chemical Name | 1-(3-(1H-Indol-3-yl)propanoyl)-6-butyl-8-(piperidin-4-ylmethyl)hexahydro-4H-pyrazino[1,2-a]pyrimidine-4,7(6H)-dione |
| InChl Key | KDAJSQJISXIJTN-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C28H39N5O3/c1-2-3-8-24-28(36)31(18-20-11-14-29-15-12-20)19-25-32(16-13-27(35)33(24)25)26(34)10-9-21-17-30-23-7-5-4-6-22(21)23/h4-7,17,20,24-25,29-30H,2-3,8-16,18-19H2,1H3 |
| SMILES Code | O=C1CCN(C(CCC2=CNC3=C2C=CC=C3)=O)C(CN4CC5CCNCC5)N1C(CCCC)C4=O |
| References | 1) Hershey LA, Coleman-Jackson R. Pharmacological Management of Dementia with Lewy Bodies. Drugs Aging. 2019 Apr;36(4):309-319. doi: 10.1007/s40266-018-00636-7. Review. PubMed PMID: 30680679; PubMed Central PMCID: PMC6435621. 2) Price DL, Koike MA, Khan A, Wrasidlo W, Rockenstein E, Masliah E, Bonhaus D. The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease. Sci Rep. 2018 Nov 1;8(1):16165. doi: 10.1038/s41598-018-34490-9. PubMed PMID: 30385782; PubMed Central PMCID: PMC6212487. |
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Novel alpha-synuclein (ASYN) misfolding inhibitor, producing multiple benefits in an animal model of Parkinsons disease
