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GSK484
AOB6992
CAS No: 1652591-81-5
Chemical Name: ((3S,4R)-3-Amino-4-hydroxypiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-indol-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride
AOBIOUS launched this product in 2015
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| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $13.05 | Total: $1,305.00 |
| 1 | 50 | $15.08 | Total: $754.00 |
| 1 | 25 | $17.69 | Total: $442.25 |
| 1 | 10 | $20.88 | Total: $208.80 |
| 1 | 5 | $24.65 | Total: $123.25 |
Data sheet
| Molecular Formula | C27H32ClN5O3 |
| Molecular Weight | 510.03 |
| CAS Numbers | 1652591-81-5 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Stock Solution Guide | 10 mMol/5.10 mg/1 mL; 5 mMol/2.55mg/1 mL in DMSO |
| Purity | 98% by HPLC |
| Synonym | GSK484; GSK-484; GSK 484. |
| IUPAC/Chemical Name | [(3S,4R)-3-amino-4-hydroxy-1-piperidinyl][2-[1-(cyclopropylmethyl)-1H-indol-2-yl]-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-methanone |
| InChl Key | MULKOGJHUZTANI-ADMBKAPUSA-N |
| InChl Code | InChI=1S/C27H31N5O3.ClH/c1-30-25-20(11-18(13-24(25)35-2)27(34)31-10-9-23(33)19(28)15-31)29-26(30)22-12-17-5-3-4-6-21(17)32(22)14-16-7-8-16;/h3-6,11-13,16,19,23,33H,7-10,14-15,28H2,1-2H3;1H/t19-,23+;/m0./s1 |
| SMILES Code | O[C@@H]1CCN(C(C2=CC(N=C(C3=CC(C=CC=C4)=C4N3CC5CC5)N6C)=C6C(OC)=C2)=O)C[C@@H]1N.Cl |
| References | 1) Jones, J.E., Causey, C.P., Knuckley, B., et al. Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential. Curr. Opin. Drug Discov. Devel. 12(5), 616-627 (2009). 2) Lewis, H.D., Liddle, J., Coote, J.E., et al. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nat. Chem. Biol. 11(3), 189-191 (2015). |
More info
Novel selective PAD4 inhibitor with half-maximum inhibitory concentration (IC50) values, in the absence of calcium, of 50 nM
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