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GSK484

Cat No: AOB6992

Condition

CAS No: 1652591-81-5

Chemical Name: ((3S,4R)-3-Amino-4-hydroxypiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-indol-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride

AOBIOUS launched this product in 2015

CITATIONS - Publications That Use AOBIOUS Product

1) Front Immunol. 2019; 10: 2088

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Quantity Discount Table - Order More To Get More Price Discount

Quantity	mg	Unit Price ($/mg or $/Unit)	Final Price
1	100	$13.05	Total: $1,305.00
1	50	$15.08	Total: $754.00
1	25	$17.69	Total: $442.25
1	10	$20.88	Total: $208.80
1	5	$24.65	Total: $123.25

Data sheet

Molecular Formula	C27H32ClN5O3
Molecular Weight	510.03
CAS Numbers	1652591-81-5
Storage Condition	0°C (short term), -20°C (long term), desiccated
Solubility	DMSO
Stock Solution Guide	10 mMol/5.10 mg/1 mL; 5 mMol/2.55mg/1 mL in DMSO
Purity	98% by HPLC
Synonym	GSK484; GSK-484; GSK 484.
IUPAC/Chemical Name	[(3S,4R)-3-amino-4-hydroxy-1-piperidinyl][2-[1-(cyclopropylmethyl)-1H-indol-2-yl]-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-methanone
InChl Key	MULKOGJHUZTANI-ADMBKAPUSA-N
InChl Code	InChI=1S/C27H31N5O3.ClH/c1-30-25-20(11-18(13-24(25)35-2)27(34)31-10-9-23(33)19(28)15-31)29-26(30)22-12-17-5-3-4-6-21(17)32(22)14-16-7-8-16;/h3-6,11-13,16,19,23,33H,7-10,14-15,28H2,1-2H3;1H/t19-,23+;/m0./s1
SMILES Code	O[C@@H]1CCN(C(C2=CC(N=C(C3=CC(C=CC=C4)=C4N3CC5CC5)N6C)=C6C(OC)=C2)=O)C[C@@H]1N.Cl
References	1) Jones, J.E., Causey, C.P., Knuckley, B., et al. Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential. Curr. Opin. Drug Discov. Devel. 12(5), 616-627 (2009). 2) Lewis, H.D., Liddle, J., Coote, J.E., et al. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nat. Chem. Biol. 11(3), 189-191 (2015).