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Enzyme Inhibitors

ML-792 View larger

ML-792

AOB37999

CAS: 1644342-14-2

Chemical Name: {(1R,2S,4R)-4-[(5-{[1-(3-Bromobenzyl)-1H-pyrazol-3-yl]carbonyl}pyrimidin-4-yl)amino]-2-hydroxycyclopentyl}methyl sulfamate

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $23.38 Total: $116.88
110 $19.80 Total: $198.00
125 $16.78 Total: $419.38
150 $14.30 Total: $715.00
1100 $12.38 Total: $1,237.50

Data sheet

Molecular FormulaC21H23BrN6O5S
Molecular Weight551.42
CAS Numbers1644342-14-2
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymML-792; ML 792; ML792
IUPAC/Chemical Name((1R,2S,4R)-4-((5-(1-(3-bromobenzyl)-1H-pyrazole-3-carbonyl)pyrimidin-4-yl)amino)-2-hydroxycyclopentyl)methyl sulfamate
InChl KeyPZCKLTWSXFDLLP-OGWOLHLISA-N
InChl CodeInChI=1S/C21H23BrN6O5S/c22-15-3-1-2-13(6-15)10-28-5-4-18(27-28)20(30)17-9-24-12-25-21(17)26-16-7-14(19(29)8-16)11-33-34(23,31)32/h1-6,9,12,14,16,19,29H,7-8,10-11H2,(H2,23,31,32)(H,24,25,26)/t14-,16-,19+/m1/s1
SMILES CodeO=S(OC[C@@H]1[C@@H](O)C[C@H](NC2=NC=NC=C2C(C3=NN(CC4=CC=CC(Br)=C4)C=C3)=O)C1)(N)=O
References1) He X, Riceberg J, Soucy T, Koenig E, Minissale J, Gallery M, Bernard H, Yang X, Liao H, Rabino C, Shah P, Xega K, Yan ZH, Sintchak M, Bradley J, Xu H, Duffey M, England D, Mizutani H, Hu Z, Guo J, Chau R, Dick LR, Brownell JE, Newcomb J, Langston S, Lightcap ES, Bence N, Pulukuri SM. Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor. Nat Chem Biol. 2017 Nov;13(11):1164-1171.

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Novel potent mechanism-based SUMO-activating enzyme (SAE) inhibitor, selectively blocking SAE enzyme activity and total SUMOylation, thus decreasing cancer cell proliferation










































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