CBHcy

Novel inhibitor of human betaine-homocysteine S-methyltransferase (BHMT)

References: 

1) Strakova J, Gupta S, Kruger WD, Dilger RN, Tryon K, Li L, Garrow TA. Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β-synthase activity and methylation capacity. Nutr Res. 2011 Jul;31(7):563-71. doi: 10.1016/j.nutres.2011.06.004. PubMed PMID: 21840473; PubMed Central PMCID: PMC3156413.

2) Strakova J, Williams KT, Gupta S, Schalinske KL, Kruger WD, Rozen R, Jiracek J, Li L, Garrow TA. Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats. Nutr Res. 2010 Jul;30(7):492-500. doi: 10.1016/j.nutres.2010.06.017. PubMed PMID: 20797482; PubMed Central PMCID: PMC2929918.

3) Collinsova M, Strakova J, Jiracek J, Garrow TA. Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice. J Nutr. 2006 Jun;136(6):1493-7. PubMed PMID: 16702310.

4) Miller CM, Szegedi SS, Garrow TA. Conformation-dependent inactivation of human betaine-homocysteine S-methyltransferase by hydrogen peroxide in vitro. Biochem J. 2005 Dec 15;392(Pt 3):443-8. PubMed PMID: 16038618; PubMed Central PMCID: PMC1316282.

5) Castro C, Gratson AA, Evans JC, Jiracek J, Collinsová M, Ludwig ML, Garrow TA. Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis. Biochemistry. 2004 May 11;43(18):5341-51. PubMed PMID: 15122900.