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CBHcy

Cat No: AOB2142

Condition

CAS No: 88096-02-0

Chemical Name: S-(4-Carboxybutyl)-D,L-homocysteine; 5-(3-Amino-3-carboxypropyl)sulfanyl-pentanoic acid

AOBIOUS launched this product in 2018

CITATIONS - Publications That Use AOBIOUS Product

1) EMBO J. 2022 Sep; 41(17): e111608

2) SCIENCE ADVANCES 18 Aug 2023 Vol 9, Issue 33

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Quantity Discount Table - Order More To Get More Price Discount

Quantity	mg	Unit Price ($/mg or $/Unit)	Final Price
1	100	$31.05	Total: $3,105.00
1	50	$35.88	Total: $1,794.00
1	25	$42.09	Total: $1,052.25
1	10	$49.68	Total: $496.80
1	5	$58.65	Total: $293.25

Data sheet

Molecular Formula	C9H17NO4S
Molecular Weight	235.29
CAS Numbers	88096-02-0
Storage Condition	0°C (short term), -20°C (long term), desiccated
Solubility	DMSO
Purity	98% by HPLC
InChl Key	BMONDXDFXRPNKQ-UHFFFAOYSA-N

More info

Novel inhibitor of human betaine-homocysteine S-methyltransferase (BHMT)

References:

1) Strakova J, Gupta S, Kruger WD, Dilger RN, Tryon K, Li L, Garrow TA. Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β-synthase activity and methylation capacity. Nutr Res. 2011 Jul;31(7):563-71. doi: 10.1016/j.nutres.2011.06.004. PubMed PMID: 21840473; PubMed Central PMCID: PMC3156413.

2) Strakova J, Williams KT, Gupta S, Schalinske KL, Kruger WD, Rozen R, Jiracek J, Li L, Garrow TA. Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats. Nutr Res. 2010 Jul;30(7):492-500. doi: 10.1016/j.nutres.2010.06.017. PubMed PMID: 20797482; PubMed Central PMCID: PMC2929918.

3) Collinsova M, Strakova J, Jiracek J, Garrow TA. Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice. J Nutr. 2006 Jun;136(6):1493-7. PubMed PMID: 16702310.

4) Miller CM, Szegedi SS, Garrow TA. Conformation-dependent inactivation of human betaine-homocysteine S-methyltransferase by hydrogen peroxide in vitro. Biochem J. 2005 Dec 15;392(Pt 3):443-8. PubMed PMID: 16038618; PubMed Central PMCID: PMC1316282.

5) Castro C, Gratson AA, Evans JC, Jiracek J, Collinsová M, Ludwig ML, Garrow TA. Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis. Biochemistry. 2004 May 11;43(18):5341-51. PubMed PMID: 15122900.