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Enzyme Inhibitors

GSK3685032 View larger

GSK3685032

AOB12591

CAS: 2170137-61-6

 

Chemical Name: 2-((6-(4-Aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl)thio)-2-phenylacetamide

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$21.00

$21.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $17.85 Total: $89.25
110 $15.12 Total: $151.20
125 $12.81 Total: $320.25
150 $10.92 Total: $546.00
1100 $9.45 Total: $945.00

Data sheet

Molecular FormulaC22H24N6OS
Molecular Weight420.54
CAS Numbers2170137-61-6
Storage Condition0°C (short term), -20°C (long term), desiccated
Purity 99% (HPLC)
SynonymGSK-3685032, GSK 3685032
IUPAC/Chemical Name2-((6-(4-Aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl)thio)-2-phenylacetamide
References1) Melissa B. Pappalardi et al., Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia, Nature Cancer volume 2, pages1002–1017 (2021)

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First-in-class potent, non-nucleoside, reversible, DNMT1-selective inhibitor (IC50: 0.17 µM), exerting robust DNA hypomethylation and gene activation, potently inhibiting growth of cancer cell lines, displaying improved tolerability and greater DNA hypomethylation than decitabine (DAC), translating into superior antitumour activity in models of AML.

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