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GSK3685032
AOB12591
CAS: 2170137-61-6
Chemical Name: 2-((6-(4-Aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl)thio)-2-phenylacetamide
6859 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $17.85 | Total: $89.25 |
| 1 | 10 | $15.12 | Total: $151.20 |
| 1 | 25 | $12.81 | Total: $320.25 |
| 1 | 50 | $10.92 | Total: $546.00 |
| 1 | 100 | $9.45 | Total: $945.00 |
Overview
First-in-class potent, non-nucleoside, reversible, DNMT1-selective inhibitor (IC50: 0.17 µM), exerting robust DNA hypomethylation and gene activation, potently inhibiting growth of cancer cell lines, displaying improved tolerability and greater DNA hypomethylation than decitabine (DAC), translating into superior antitumour activity in models of AML.
Chemical Properties
| Molecular Formula | C22H24N6OS |
| Molecular Weight | 420.54 |
| CAS Numbers | 2170137-61-6 |
| Purity | 99% (HPLC) |
| IUPAC/Chemical Name | 2-((6-(4-Aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl)thio)-2-phenylacetamide |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
GSK-3685032, GSK 3685032
References
1) Melissa B. Pappalardi et al., Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia, Nature Cancer volume 2, pages1002–1017 (2021)
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