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Enzyme Inhibitors

GW280264X View larger

GW280264X

AOB3632

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$31.00

$31.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $26.35 Total: $131.75
110 $22.32 Total: $223.20
125 $18.91 Total: $472.75
150 $16.12 Total: $806.00
1100 $13.95 Total: $1,395.00

Data sheet

Molecular FormulaC28H41N5O6S
Molecular Weight575.72
CAS Numbers 866924-39-2
Storage Condition0°C (short term), -20°C (long term), desiccated
Solubility57.57mg/mL in DMSO
Purity98% by HPLC
IUPAC/Chemical NamePhenylmethyl N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]carbamate
InChl KeySKJLITFHSZNZMQ-SGNDLWITSA-N
SMILES CodeCCC[C@H](N(C=O)O)[C@H](C(N[C@H](C(NC1=NC=CS1)=O)CCCCNC(OCC2=CC=CC=C2)=O)=O)CC(C)C
References1) Hundhausen et al (2003) The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood 102 1186 PMID: 12714508

2) Sommer et al (2019) ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury Brain Behav.Immun. 80 129 PMID: 30851378
PubChem ID91885425

More info

Inhibitor of of the metalloproteinase ADAM17; Inhibitor of the constitutive and the PMA-inducible CX3CL1 cleavage, blocking TACE as well as ADAM10

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