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UCPH-101
AOB1086
CAS: 1118460-77-7
Chemical Name: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-
3-carbonitrile
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $6.75 | Total: $675.00 |
| 1 | 50 | $7.80 | Total: $390.00 |
| 1 | 25 | $9.15 | Total: $228.75 |
| 1 | 10 | $10.80 | Total: $108.00 |
| 1 | 5 | $12.75 | Total: $63.75 |
Data sheet
| Molecular Formula | C27H22N2O3 |
| Molecular Weight | 422.48 |
| CAS Numbers | 1118460-77-7 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Stock Solution Guide | DMSO 25 mg per mL |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 2-amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(1-naphthalenyl)-5-oxo-4H-1-benzopyran-3-carbonitrile |
| InChl Key | YBMGNDPBARCLFT-YDONVPIESA-N |
| InChl Code | InChI=1S/C27H22N2O3/c1-31-19-11-9-17(10-12-19)25-22(15-28)27(29)32-24-14-18(13-23(30)26(24)25)21-8-4-6-16-5-2-3-7-20(16)21/h2-12,18,25H,13-14,29H2,1H3/t18-,25?/m1/s1 |
| SMILES Code | COC(C=C1)=CC=C1C2C(C#N)=C(N)OC3=C2C(C[C@@H](C4=C(C=CC=C5)C5=CC=C4)C3)=O |
| References | 1) Erichsen, M.N., et al. Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101). J. Med Chem. 53(19), 7180-7191 (2010). 2) Abrahamsen, B., et al. Allosteric modulation of an excitatory amino acid transporter: The subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain. J. Neurosci. 33(3), 1068-1087 (2013). |
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Potent and selective EAAT1 inhibitor
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