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Enzyme Inhibitors

UCPH-101 View larger

UCPH-101

AOB1086

CAS: 1118460-77-7

 

Chemical Name: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-

                              3-carbonitrile

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $12.75 Total: $63.75
110 $10.80 Total: $108.00
125 $9.15 Total: $228.75
150 $7.80 Total: $390.00
1100 $6.75 Total: $675.00

Data sheet

Molecular FormulaC27H22N2O3
Molecular Weight422.48
CAS Numbers1118460-77-7
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Stock Solution GuideDMSO 25 mg per mL
Purity98% by HPLC
IUPAC/Chemical Name2-amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(1-naphthalenyl)-5-oxo-4H-1-benzopyran-3-carbonitrile
InChl KeyYBMGNDPBARCLFT-YDONVPIESA-N
InChl CodeInChI=1S/C27H22N2O3/c1-31-19-11-9-17(10-12-19)25-22(15-28)27(29)32-24-14-18(13-23(30)26(24)25)21-8-4-6-16-5-2-3-7-20(16)21/h2-12,18,25H,13-14,29H2,1H3/t18-,25?/m1/s1
SMILES CodeCOC(C=C1)=CC=C1C2C(C#N)=C(N)OC3=C2C(C[C@@H](C4=C(C=CC=C5)C5=CC=C4)C3)=O
References1) Erichsen, M.N., et al. Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101). J. Med Chem. 53(19), 7180-7191 (2010).

2) Abrahamsen, B., et al. Allosteric modulation of an excitatory amino acid transporter: The subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain. J. Neurosci. 33(3), 1068-1087 (2013).

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Potent and selective EAAT1 inhibitor

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