Epigenetics

 NR1 View larger

NR1

AOB33900

CAS No: 2216763-38-9

 

Chemical Name: 4-Bromo-6-((3,4-dichlorophenyl)thio)-1-(4-(dimethylcarbamoyl)benzyl)-1H-indole-2-carboxylic acid

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$37.00

$37.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

Quantity (mg or Unit)Unit Price ($/mg or $/Unit)Final Price
100 $16.65 Total: $1,665.00
50 $19.24 Total: $962.00
25 $22.57 Total: $564.25
10 $26.64 Total: $266.40
5 $31.45 Total: $157.25

Data sheet

Molecular FormulaC25H19BrCl2N2O3S
Molecular Weight578.30
CAS Numbers2216763-38-9
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity 99% (HPLC)
SynonymNR1; NR-1; NR 1
IUPAC/Chemical Name4-Bromo-6-((3,4-dichlorophenyl)thio)-1-(4-(dimethylcarbamoyl)benzyl)-1H-indole-2-carboxylic acid
InChl KeyMJYFVDNMTKLGTH-UHFFFAOYSA-N
InChl CodeInChI=1S/C25H19BrCl2N2O3S/c1-29(2)24(31)15-5-3-14(4-6-15)13-30-22-11-17(34-16-7-8-20(27)21(28)10-16)9-19(26)18(22)12-23(30)25(32)33/h3-12H,13H2,1-2H3,(H,32,33)
SMILES CodeO=C(C(N1CC2=CC=C(C(N(C)C)=O)C=C2)=CC3=C1C=C(SC4=CC=C(Cl)C(Cl)=C4)C=C3Br)O
ReferencesMahoney SJ, Narayan S, Molz L, Berstler LA, Kang SA, Vlasuk GP, Saiah E. A small molecule inhibitor of Rheb selectively targets mTORC1 signaling. Nat Commun. 2018 Feb 7;9(1):548. doi: 10.1038/s41467-018-03035-z. PubMed PMID: 29416044; PubMed Central PMCID: PMC5803267.

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Novel inhibitor of Rheb, selectively targeting mTORC1 signaling

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