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Zanubrutinib

Cat No: AOB13246

Condition

CAS: 1691249-45-2

Chemical Name: BGB-3111; (7S)-2-(4-Phenoxyphenyl)-7-(1-prop-2-enoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

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Quantity	mg	Unit Price ($/mg or $/Unit)	Final Price
1	5	$41.65	Total: $208.25
1	10	$35.28	Total: $352.80
1	25	$29.89	Total: $747.25
1	50	$25.48	Total: $1,274.00
1	100	$22.05	Total: $2,205.00

Data sheet

Molecular Formula	C27H29N5O3
Molecular Weight	471.56
CAS Numbers	1691249-45-2 (S-isomer)
Storage Condition	0°C (short term), -20°C (long term), desiccated
Solubility	DMSO
Purity	98% by HPLC
Synonym	BGB-3111; BGB 3111; BGB3111; Zanubrutinib; Brukinsa.
IUPAC/Chemical Name	(7S)-4,5,6,7-Tetrahydro-7-[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
InChl Key	RNOAOAWBMHREKO-QFIPXVFZSA-N
InChl Code	InChI=1S/C27H29N5O3/c1-2-23(33)31-16-13-18(14-17-31)22-12-15-29-27-24(26(28)34)25(30-32(22)27)19-8-10-21(11-9-19)35-20-6-4-3-5-7-20/h2-11,18,22,29H,1,12-17H2,(H2,28,34)/t22-/m0/s1
SMILES Code	O=C(C1=C2NCC[C@@H](C3CCN(C(C=C)=O)CC3)N2N=C1C4=CC=C(OC5=CC=CC=C5)C=C4)N
References	1) Wong J, Cher L, Griffiths J, Cohen A, Huang J, Wang L, Gregory G, Opat S. Efficacy of Zanubrutinib in the Treatment of Bing-Neel Syndrome. Hemasphere. 2018 Nov 30;2(6):e155. doi: 10.1097/HS9.0000000000000155. eCollection 2018 Dec. PubMed PMID: 31723793; PubMed Central PMCID: PMC6745965. 2) Zou YX, Zhu HY, Li XT, Xia Y, Miao KR, Zhao SS, Wu YJ, Wang L, Xu W, Li JY. The impacts of zanubrutinib on immune cells in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma. Hematol Oncol. 2019 Oct;37(4):392-400. doi: 10.1002/hon.2667. Epub 2019 Sep 13. PubMed PMID: 31420873.