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Pazopanib

Cat No: AOB87481

Condition

CAS: 444731-52-6

Chemical Name: GW786034; 5-[[4-[(2,3-Dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide

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Quantity Discount Table - Order More To Get More Price Discount

Quantity	mg	Unit Price ($/mg or $/Unit)	Final Price
1	5	$9.35	Total: $46.75
1	10	$7.92	Total: $79.20
1	25	$6.71	Total: $167.75
1	50	$5.72	Total: $286.00
1	100	$4.95	Total: $495.00

Data sheet

Molecular Formula	C21H23N7O2S
Molecular Weight	437.52
CAS Numbers	444731-52-6
Storage Condition	0°C (short term), -20°C (long term), desiccated
Solubility	DMSO
Purity	99% (HPLC)
Synonym	GW786034; GW786034; GW 786034; Pazopanib; Votrient.
IUPAC/Chemical Name	5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide
InChl Key	CUIHSIWYWATEQL-UHFFFAOYSA-N
InChl Code	InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)
SMILES Code	O=S(C1=CC(NC2=NC=CC(N(C3=CC4=NN(C)C(C)=C4C=C3)C)=N2)=CC=C1C)(N)=O
References	1) Jeldres C, Sun M, Perrotte P, Karakiewicz PI. Pazopanib trial data cannot support first-line use. Nat Rev Urol. 2010 Jun;7(6):307-8. PubMed PMID: 20535144. 2) Altorki N, Lane ME, Bauer T, Lee PC, Guarino MJ, Pass H, Felip E, Peylan-Ramu N, Gurpide A, Grannis FW, Mitchell JD, Tachdjian S, Swann RS, Huff A, Roychowdhury DF, Reeves A, Ottesen LH, Yankelevitz DF. Phase II Proof-of-Concept Study of Pazopanib Monotherapy in Treatment-Naive Patients With Stage I/II Resectable Non-Small-Cell Lung Cancer. J Clin Oncol. 2010 Jun 1. [Epub ahead of print] PubMed PMID: 20516450.

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Novel inhibitor of multiple protein tyrosine kinases, selectively inhibiting vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), blocking tumour growth and inhibiting angiogenesis