Kinase Inhibitors

Poseltinib View larger

Poseltinib

AOB14400

CAS: 1353552-97-2

 

Chemical Name: HM71224; LY3337641; N-[3-[2-[4-(4-Methylpiperazin-1-yl)anilino]furo[3,2-d]pyrimidin-4-yl]oxyphenyl]prop-2-enamide

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$17.00

$17.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $7.65 Total: $765.00
150 $8.84 Total: $442.00
125 $10.37 Total: $259.25
110 $12.24 Total: $122.40
15 $14.45 Total: $72.25

Data sheet

Molecular FormulaC26H26N6O3
Molecular Weight470.53
CAS Numbers1353552-97-2
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymPoseltinib; HM 71224; HM-71224; HM71224; LY 3337641; LY3337641; LY-3337641
IUPAC/Chemical NameN-(3-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide
InChl KeyLZMJNVRJMFMYQS-UHFFFAOYSA-N
InChl CodeInChI=1S/C26H26N6O3/c1-3-23(33)27-19-5-4-6-21(17-19)35-25-24-22(11-16-34-24)29-26(30-25)28-18-7-9-20(10-8-18)32-14-12-31(2)13-15-32/h3-11,16-17H,1,12-15H2,2H3,(H,27,33)(H,28,29,30)
SMILES CodeC=CC(NC1=CC=CC(OC2=C(OC=C3)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=N2)=C1)=O
References1) Park JK, Byun JY, Park JA, Kim YY, Lee YJ, Oh JI, Jang SY, Kim YH, Song YW, Son J, Suh KH, Lee YM, Lee EB. HM71224, a novel Bruton's tyrosine kinase inhibitor, suppresses B cell and monocyte activation and ameliorates arthritis ina mouse model: a potential drug for rheumatoid arthritis. Arthritis Res Ther. 2016 Apr 18;18:91. doi: 10.1186/s13075-016-0988-z. PubMed PMID: 27090981; PubMed Central PMCID: PMC4835877.

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Novel inhibitor of Bruton's tyrosine kinase (BTK), preventing the activation of the B-cell antigen receptor (BCR) signaling pathway.and the activation of BTK-mediated inflammatory pathways

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