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> Pathway Inhibitors>Enzyme Inhibitors>Kinase Inhibitors>1-NA-PP1

Kinase Inhibitors

1-NA-PP1 View larger

1-NA-PP1

AOB3852

CAS: 221243-82-9

 

Chemical Name: 1NA-PP1; PP1 Analog I; 4-Amino-1-tert-butyl-3-(1′-naphthyl)pyrazolo[3,4-d]pyrimidine

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$15.00

$15.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $12.75 Total: $63.75
110 $10.80 Total: $108.00
125 $9.15 Total: $228.75
150 $7.80 Total: $390.00
1100 $6.75 Total: $675.00

Data sheet

Molecular FormulaC24H27N5O3
Molecular Weight433.5
CAS Numbers1316214-52-4
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMF: 30 mg/ml DMF:PBS (pH 7.2) (1:5): 0.15 mg/ml DMSO: 1 mg/ml Ethanol: 2 mg/ml
Purity98% by HPLC
Synonym1-Naphthyl-PP1 PP1 Analog
IUPAC/Chemical Name1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
InChl KeyXSHQBIXMLULFEV-UHFFFAOYSA-N
InChl CodeInChI=1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22)
SMILES CodeNC1=C(C(C2=C(C=CC=C3)C3=CC=C2)=NN4C(C)(C)C)C4=NC=N1
References1) Bishop, A.C., Kung, C.y., Shah, K., et al. Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J. Am. Chem. Soc. 121, 627-631 (1999).

2) Bishop, A.C., Ubersax, J.A., Petsch, D.T., et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407, 395-401 (2000).

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Potent, reversible, ATP-competitive, and cell-permeable inhibitor of Src-family tyrosine kinases

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